Neural pathways involved in mutual interactions between optic lobe circadian pacemakers in the cricketGryllus bimaculatus
Neural pathways involved in mutual interactions between optic lobe circadian pacemakers in the cricketGryllus bimaculatus
复制标题
蟋蟀视叶昼夜节律起搏器之间相互作用的神经通路
DOI：
--
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
K. Tomioka
中科院分区：
文献类型：
--
作者：
M. Yukizane;K. Tomioka
蟋蟀的昼夜运动节律主要由一对视叶昼夜节律起搏器产生。两个起搏器相互作用，以保持运动活动的稳定时间结构。这种相互作用对活动节律有两个主要影响，即，自由运行期的相位依赖性调制和伴侣起搏器驱动的活动的相位依赖性抑制。这两种效应都是由神经通路介导的，因为它们在连接视神经髓质和小叶的视柄单侧切断后立即被消除。通过记录自发活动，在13小时的光13小时黑暗的周期，视神经单侧切断后，对侧的视柄被部分破坏的小叶附近的神经通路进行了检查。当视柄的背侧部分被切断时，运动节律主要分为两部分：一部分很容易被夹带到给定的明暗周期，另一部分则在freerunning期间具有明显的波动，其中freerunning成分的周期在其主观的夜晚或白天分别发生时被延长或缩短。在这两种组分中也观察到活性的相位依赖性调制。然而，切断腹侧的一半的视柄导致的外观只的freerunning组件，既没有相位依赖性调制的freerunning期间，也没有观察到活动水平的变化。这些结果表明，神经元驱动的相互作用和明显的活动节奏运行在腹侧一半的近端视柄，包括大的延髓神经元的轴突投射到大脑叶和对侧延髓。
The circadian locomotor rhythm of the cricketGryllus bimaculatus is primarily generated by a pair of optic lobe circadian pacemakers. The two pacemakers mutually interact to keep a stable temporal structure in the locomotor activity. The interaction has two principal effects on the activity rhythm, i.e., phase-dependent modulation of the freerunning period and phase-dependent suppression of activity driven by the partner pacemaker. Both effects were mediated by neural pathways, since they were immediately abolished after the optic stalk connecting the optic medulla to the lobula was unilaterally severed. The neural pathways were examined by recording locomotor activity, under a 13 h light to 13 h dark cycle, after the optic nerves were unilaterally severed and the contralateral optic stalk was partially destroyed near the lobula. When the dorsal half of the optic stalk was severed, locomotor rhythm mostly split into two components: one was readily entrained to the given light-dark cycle and the other freeran with a marked fluctuation in freerunning period, where the period of the freerunning component was lengthened or shortened when the onset of the entrained component occurred during its subjective night or day, respectively. The phase-dependent modulation of activity was also observed in both components. However, severance of the ventral half of the optic stalk resulted in appearance only of the freerunning component; neither the phase-dependent modulation of its freerunning period nor the change in activity level was observed. These results suggest that neurons driving the mutual interaction and the overt activity rhythm run in the ventral half of the proximal optic stalk that includes axons of large medulla neurons projecting to the cerebral lobe and the contralateral medulla.
Bulla gouldiana 眼部昼夜节律起搏器之间的相互耦合。
DOI：
10.1126/science.6857272
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Roberts,MH;Block,GD
通讯作者：
Block,GD
视交叉上核移植可恢复老年仓鼠的昼夜节律功能。
影响因子：
2.9
作者：
Viswanathan,N;Davis,FC
通讯作者：
Davis,FC