Podocalyxin-Like Protein 1 Expression and Correlation with Clinical Characteristics in Epithelial Serous and Mucinous Ovarian Carcinoma and Tumor-Like Lesions
Podocalyxin-Like Protein 1 Expression and Correlation with Clinical Characteristics in Epithelial Serous and Mucinous Ovarian Carcinoma and Tumor-Like Lesions
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上皮浆液性和粘液性卵巢癌及肿瘤样病变中足萼蛋白样蛋白 1 的表达及其与临床特征的相关性
DOI：
10.1159/000338078
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发表时间：
2012-06
期刊：
影响因子：
5
通讯作者：
Chen, Huaizeng
中科院分区：
文献类型：
--
作者：
Ye, Feng;Hu, Ying;Zhou, Caiyun;Hu, Yuting;Chen, Huaizeng
目的：足萼蛋白样蛋白1（PCLP1）可能参与肿瘤的侵袭和转移。然而，到目前为止，PCLP1在上皮性卵巢癌进展中的作用尚未得到研究。方法：检测PCLP1的表达
Objective: Podocalyxin-like protein 1 (PCLP1) may be involved in the invasion and metastasis of tumors. However, to date the role of PCLP1 in the progression of epithelial ovarian carcinoma has not been investigated. Methods: PCLP1 expression was examined by immunohistochemistry in 471 cases with various degrees of ovarian epithelial lesions, including 46 cases of normal ovarian epithelial tissue, 105 benign serous tumors, 74 borderline serous tumors, 94 serous carcinomas, 58 benign mucinous tumors, 50 borderline mucinous tumors and 44 mucinous carcinomas. Associations between PCLP1 expression and various clinical characteristics were analyzed. Results: PCLP1 expression in mucinous carcinoma and borderline mucinous tumor tissues was found to be significantly lower than that observed in normal and benign mucinous tumor tissue. In addition, PCLP1 expression was significantly lower in mucinous carcinoma patients in advanced clinical stage and with poor differentiation of tumor cells. No positive results were observed in serous carcinomas. Conclusions: Our findings suggest that PCLP1 may be involved in the progression of ovarian mucinous lesions but not in serous lesions. Low PCLP1 expression may be a potential predictor of a poor prognosis in mucinous carcinomas.
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影响因子：
4.4
作者：
Kershaw, DB;Wiggins, JE;Wiggins, RC
通讯作者：
Wiggins, RC
影响因子：
5.2
作者：
Choo, Andre B.;Tan, Heng Liang;Yap, Miranda
通讯作者：
Yap, Miranda
影响因子：
5
作者：
Pan, Yongmiao;Jiao, Jie;Chen, Huaizeng
通讯作者：
Chen, Huaizeng
DOI：
10.1084/jem.187.12.1965
发表时间：
1998-06-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Sassetti C;Tangemann K;Singer MS;Kershaw DB;Rosen SD
通讯作者：
Rosen SD
影响因子：
9.7
作者：
GARDNER, MJ;JONES, LMH;TURNER, GA
通讯作者：
TURNER, GA