Metabolism and Vascular Retinopathies: Current Perspectives and Future Directions.
Metabolism and Vascular Retinopathies: Current Perspectives and Future Directions.
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DOI：
10.3390/diagnostics12040903
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发表时间：
2022-04-05
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影响因子：
--
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视网膜是人体内代谢最活跃的器官之一。虽然它是大脑的延伸，但视网膜的代谢需求以及视网膜中不同细胞类型之间的代谢交换与大脑的代谢需求并不相同。视网膜光感受器通过在其胞质溶胶中发生的有氧糖酵解将大部分葡萄糖转化为乳酸，然而在光感受器中存在大量的线粒体。本文是一个重点审查的代谢失调，视网膜病变与潜在的血管异常与异常线粒体代谢和缺氧诱导因子（HIF）依赖的发病机制。特别强调了早产儿视网膜病变（ROP），年龄相关性黄斑变性（AMD）和糖尿病视网膜病变（DR）中不同细胞类型之间的代谢交换。这些增生性视网膜病变之间的代谢相似性进行了讨论。
The retina is one of the most metabolically active organs in the body. Although it is an extension of the brain, the metabolic needs of the retina and metabolic exchanges between the different cell types in the retina are not the same as that of the brain. Retinal photoreceptors convert most of the glucose into lactate via aerobic glycolysis which takes place in their cytosol, yet there are immense numbers of mitochondria in photoreceptors. The present article is a focused review of the metabolic dysregulation seen in retinopathies with underlying vascular abnormalities with aberrant mitochondrial metabolism and Hypoxia-inducible factor (HIF) dependent pathogenesis. Special emphasis has been paid to metabolic exchanges between different cell types in retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). Metabolic similarities between these proliferative retinopathies have been discussed.
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影响因子：
3.5
作者：
Du J;Zhu S;Lim RR;Chao JR
通讯作者：
Chao JR
影响因子：
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作者：
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作者：
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Usuda, Nobuteru
DOI：
10.1073/pnas.222551899
发表时间：
2002-11-12
影响因子：
11.1
作者：
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通讯作者：
Hollyfield, JG
高氧以MYC依赖性方式抑制视网膜内皮细胞的增殖。
DOI：
10.3390/life11070614
发表时间：
2021-06-25
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Singh C;Benos A;Grenell A;Rao S;Anand-Apte B;Sears JE
通讯作者：
Sears JE