Increased TLR/MyD88 signaling in patients with obesity: is there a link to COVID-19 disease severity?
Increased TLR/MyD88 signaling in patients with obesity: is there a link to COVID-19 disease severity?
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DOI：
10.1038/s41366-021-00768-8
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Potter JJ
中科院分区：
文献类型：
--
作者：
Cuevas AM;Clark JM;Potter JJ
COVID-19是一种由冠状病毒引起的大流行疾病，被设计为SARS CoV-2，其临床表现差异很大，大多数患者症状轻微或无症状，但其他人会发展为多器官衰竭甚至死亡的恶性疾病。来自不同人群的累积数据表明，肥胖是该疾病严重演变的一个风险因素，然而，解释这种关联的机制尚不清楚。COVID-19的不祥演变被归因于加剧的炎症反应，被设计为“细胞因子风暴”，通过病原体相关分子模式激活toll样受体（TLR），增加细胞因子/趋化因子的产生，从而触发炎症下游反应，部分由适配器分子髓样分化因子88 （MyD88）介导。先前的研究报道了MyD88和TLRs在肥胖人群中的表达增加，主要是在那些有代谢并发症的人群中。因此，我们假设，潜在的Myd88/TLR信号增加可能使肥胖患者对SARS CoV-2感染产生夸大和危险的炎症反应，至少在一定程度上解释了COVID-19的更高严重程度。此外，肥胖人群中的MyD88/TLR信号可能在几种慢性疾病的发展中起作用。
COVID-19 is a pandemic disease caused by a coronavirus, designed as SARS CoV-2, whose clinical presentation is widely variable, with most patients having mild or no symptoms, but others developing a malign disease with multi-organ failure and even death. Accumulating data from different populations have shown that obesity is a risk factor for a severe evolution of the disease, however, the mechanisms that explain this association are not clearly understood. An ominous evolution of COVID-19 has been attributed to an exacerbated inflammatory response, designed as “cytokine storm” with augmented production of cytokines/chemokines through the activation of toll-like receptors (TLR) by pathogen-associated molecular patterns, that triggers an inflammatory downstream response, mediated in part by the adaptor molecule, myeloid differentiation factor 88 (MyD88). Previous studies have reported an increased expression of MyD88 and TLRs in people with obesity, mainly in those with metabolic complications. Therefore, we hypothesize, that an underlying increased Myd88/TLR signaling may predispose to patients with obesity to develop an exaggerated and dangerous inflammatory reaction against SARS CoV-2 infection, explaining at least in part, the higher severity of COVID-19. In addition, MyD88/TLR signaling in people with obesity could have a role in the development of several chronic diseases.
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DOI：
10.1056/nejmoa2022926
发表时间：
2020-11-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
RECOVERY Collaborative Group;Horby P;Mafham M;Linsell L;Bell JL;Staplin N;Emberson JR;Wiselka M;Ustianowski A;Elmahi E;Prudon B;Whitehouse T;Felton T;Williams J;Faccenda J;Underwood J;Baillie JK;Chappell LC;Faust SN;Jaki T;Jeffery K;Lim WS;Montgomery A;Rowan K;Tarning J;Watson JA;White NJ;Juszczak E;Haynes R;Landray MJ
通讯作者：
Landray MJ
DOI：
10.1186/1476-9255-9-48
发表时间：
2012-11-28
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Ahmad R;Al-Mass A;Atizado V;Al-Hubail A;Al-Ghimlas F;Al-Arouj M;Bennakhi A;Dermime S;Behbehani K
通讯作者：
Behbehani K
影响因子：
5.8
作者：
Moreno-Eutimio, Mario Adan;Lopez-Macias, Constantino;Pastelin-Palacios, Rodolfo
通讯作者：
Pastelin-Palacios, Rodolfo
影响因子：
9
作者：
Channappanavar R;Perlman S
通讯作者：
Perlman S
影响因子：
8.3
作者：
Angelopoulou, Athina;Alexandris, Nikos;Poulas, Konstantinos
通讯作者：
Poulas, Konstantinos