Aging-associated alterations in contractility of rat mesenteric lymphatic vessels.
Aging-associated alterations in contractility of rat mesenteric lymphatic vessels.
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DOI：
10.1111/j.1549-8719.2011.00107.x
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Gashev AA
中科院分区：
文献类型：
--
作者：
Nagai T;Bridenbaugh EA;Gashev AA
目的探讨9月龄和24月龄雄性Fisher-344大鼠肠系膜淋巴管泵送（MLV）的年龄相关性变化。应用L-NAME前后分别测定离体MLV淋巴直径、收缩幅度、收缩频率和分级泵流量。这些数据表明，老年MLV的淋巴泵严重减弱，包括淋巴收缩幅度、收缩频率降低，因此淋巴泵活性降低。数据还表明，在老年大鼠MLV中不存在施加的流动梯度产生的剪切依赖性松弛，并且成年和老年MLV对这种剪切的敏感性不能通过一氧化氮合酶阻断来消除。这些数据为成人和老年MLV的淋巴区域异质性提供了新的证据。在MLV中，肌生成反应的强直和相位成分与一氧化氮剪切依赖性释放之间的持续相互作用主要决定了收缩活动的水平；可能存在另一种依赖于剪切但不依赖于no的调节机制。衰老显著削弱了MLV的收缩能力，这将使这个淋巴网络在静息状态下降低总淋巴流量，并限制了它对老年人水肿挑战的反应能力。
To evaluate the age-related changes in pumping of mesenteric lymphatic vessels (MLV) in male 9-mo and 24-mo old Fisher-344 rats. Lymphatic diameters, contraction amplitude, contraction frequency and fractional pump flow were determined in isolated MLV before and after L-NAME application. The data demonstrate a severe weakening of the lymphatic pump in aged MLV including diminished lymphatic contraction amplitude, contraction frequency and as a result, - lymphatic pump activity. The data also suggest that the imposed flow gradient-generated shear-dependent relaxation does not exist in aged rat MLV, and the sensitivity of both adult and aged MLV to such shear cannot be eliminated by nitric oxide synthases blockade. These data provide new evidence of lymphatic regional heterogeneity for both adult and aged MLV. In MLV, a constant interplay between the tonic and phasic components of the myogenic response and the shear-dependent release of nitric oxide predominantly determines the level of contractile activity; the existence of another shear-dependent but NO-independent regulatory mechanism is likely present. Aging remarkably weakens MLV contractility, which would predispose this lymphatic network to lower total lymph flow in resting conditions and limit the ability it’s to respond to an edemagenic challenge in the elderly.
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影响因子：
3.9
作者：
HOLLANDER, D;DADUFALZA, V
通讯作者：
DADUFALZA, V
DOI：
10.1016/j.pathophys.2009.09.002
发表时间：
2010-09
期刊：
Pathophysiology : the official journal of the International Society for Pathophysiology
影响因子：
--
作者：
Gashev AA;Zawieja DC
通讯作者：
Zawieja DC
影响因子：
1.4
作者：
Davis, Michael J.;Zawieja, David C.;Gashev, Anatoliy A.
通讯作者：
Gashev, Anatoliy A.
影响因子：
5.5
作者：
Gasheva, Olga Yu.;Zawieja, David C.;Gashev, Anatoliy A.
通讯作者：
Gashev, Anatoliy A.
DOI：
10.1152/ajpregu.1998.274.3.r790
发表时间：
1998-03-01
影响因子：
2.8
作者：
Mizuno, R;Koller, A;Kaley, G
通讯作者：
Kaley, G