Applications of positron emission tomography in the newborn nursery.
Applications of positron emission tomography in the newborn nursery.
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DOI：
10.1053/j.semperi.2009.10.004
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发表时间：
2010-02
影响因子：
3.4
通讯作者：
Chugani HT
中科院分区：
文献类型：
--
作者：
Kannan S;Chugani HT
正电子发射断层扫描（PET）是一种相对非侵入性的成像测试，能够基于细胞水平上的化学功能和/或受体表达的紊乱来检测不同器官中的异常。PET脑成像已被证明是一个强大的诊断工具，用于检测与各种神经系统疾病相关的神经化学异常，以及研究正常的大脑发育。虽然它在检测神经系统异常中的应用已经在成人和儿科得到了很好的描述，但它在新生儿保育中的应用尚未得到充分的探索。使用PET成像早期检测继发于宫内和围产期损伤的脑损伤可以为预后和制定早期治疗提供新的见解。在这篇综述中，作者描述了PET成像在新生儿保育中的应用，特别是与新生儿缺氧缺血性脑病、新生儿癫痫发作和新生儿期神经炎症中观察到的代谢变化的检测相关。
Positron emission tomography (PET) is a relatively non-invasive imaging test that is able to detect abnormalities in different organs based on derangements in the chemical functions and/or receptor expression at the cellular level. PET imaging of the brain has been shown to be a powerful diagnostic tool for detecting neurochemical abnormalities associated with various neurologic disorders as well as to study normal brain development. Although its use in detecting neurological abnormalities has been well described in adults and pediatrics, it application in the newborn nursery has not been explored adequately. Early detection of brain injury secondary to intrauterine and perinatal insults using PET imaging can provide new insight in prognosis and in instituting early therapy. In this review, the authors describe applications of PET imaging in the newborn nursery specifically related to the detection of metabolic changes seen in hypoxic ischemic encephalopathy, neonatal seizures and neuroinflammation in the neonatal period.
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影响因子：
56.9
作者：
CHUGANI, HT;PHELPS, ME
通讯作者：
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作者：
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