Antibiotic Resistance Increases with Local Temperature.
Antibiotic Resistance Increases with Local Temperature.
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DOI：
10.1038/s41558-018-0161-6
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发表时间：
2018-06
影响因子：
30.7
通讯作者：
Brownstein JS
中科院分区：
文献类型：
--
作者：
MacFadden DR;McGough SF;Fisman D;Santillana M;Brownstein JS
导致人类感染的细菌可能对常用的抗生素产生抗药性。抗菌素耐药性(在细菌和其他微生物中)导致全球范围内的严重发病率，一些估计表明，到2050年，可归因性死亡率可能高达1000万，-。细菌中的抗生素耐药性被认为在很大程度上是在抗生素使用的选择性压力下产生的；然而，其他因素可能有助于人群水平的抗生素耐药性增加。我们探索了气候(温度)和其他因素在美国各地抗生素耐药性分布中的作用，这里我们表明，当地气温和人口密度的增加与常见病原体的抗生素耐药性(耐药率)的增加有关。我们发现，跨地区气温每升高10 °C，对常见病原菌大肠埃希菌、肺炎克雷伯菌和金黄色葡萄球菌的耐药性分别增加4.2%、2.2%和2.7%。在这项生态学研究中，温度和抗生素耐药性之间的联系在大多数类别的抗生素和病原体中是一致的，并且可能随着时间的推移而加强。这些发现表明，面对不断增长的人口和气候变化，目前对抗生素耐药性负担的预测可能被严重低估。
Bacteria that cause infections in humans can develop or acquire resistance to antibiotics commonly used against them,. Antimicrobial resistance (in bacteria and other microbes) causes significant morbidity worldwide, and some estimates indicate the attributable mortality could reach up to 10 million by 2050, –. Antibiotic resistance in bacteria is believed to develop largely under the selective pressure of antibiotic use; however, other factors may contribute to population level increases in antibiotic resistance,. We explored the role of climate (temperature) and additional factors on the distribution of antibiotic resistance across the United States, and here we show that increasing local temperature as well as population density are associated with increasing antibiotic resistance (percent resistant) in common pathogens. We found that an increase in temperature of 10 °C across regions was associated with an increases in antibiotic resistance of 4.2%, 2.2%, and 2.7% for the common pathogensEscherichia coli,Klebsiella pneumoniaeandStaphylococcus aureus. The associations between temperature and antibiotic resistance in this ecological study are consistent across most classes of antibiotics and pathogens and may be strengthening over time. These findings suggest that current forecasts of the burden of antibiotic resistance could be significant underestimates in the face of a growing population and climate change.
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DOI：
10.1056/nejmra0904124
发表时间：
2010-05-13
期刊：
The New England journal of medicine
影响因子：
--
作者：
Peleg AY;Hooper DC
通讯作者：
Hooper DC
影响因子：
168.9
作者：
Holmes, Alison H.;Moore, Luke S. P.;Piddock, Laura J. V.
通讯作者：
Piddock, Laura J. V.
DOI：
10.1093/cid/cis581
发表时间：
2012-10
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Hilty M;Betsch BY;Bögli-Stuber K;Heiniger N;Stadler M;Küffer M;Kronenberg A;Rohrer C;Aebi S;Endimiani A;Droz S;Mühlemann K
通讯作者：
Mühlemann K
影响因子：
11.8
作者：
Boucher, Helen W.;Talbot, George H.;Bartlett, John
通讯作者：
Bartlett, John
DOI：
10.1056/nejmra1003071
发表时间：
2011-07-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Relman DA
通讯作者：
Relman DA