Chemerin and adiponectin contribute reciprocally to metabolic syndrome.
Chemerin and adiponectin contribute reciprocally to metabolic syndrome.
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DOI：
10.1371/journal.pone.0034710
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lee JW
中科院分区：
文献类型：
--
作者：
Chu SH;Lee MK;Ahn KY;Im JA;Park MS;Lee DC;Jeon JY;Lee JW
肥胖和代谢综合征（MetS）被认为是慢性炎症状态。Chemerin是一种新的脂肪因子，可能在MetS和炎症的联系中发挥重要作用。我们研究了在明显健康的超重和肥胖成年人中chemerin与炎症标志物和MetS特征的相关性。我们研究了92名成年人; 59名男性和33名女性，平均体重指数（BMI）为28.15±5.08 kg/m2。测量人体测量参数、胰岛素抵抗指数、血脂和炎症标志物，包括高敏C反应蛋白（hsCRP）、正五聚蛋白3（PTX 3）、脂联素和趋化蛋白。在控制年龄、性别和BMI的情况下，血清chemerin水平与体脂和血清甘油三酯呈正相关，与脂联素和高密度脂蛋白胆固醇（HDL-C）呈负相关，与hsCRP或PTX 3水平变化无关。在低、中和高chemerin组中，高chemerin个体更可能具有较低的HDL-C。相反，低脂联素组的个体更有可能具有较低的HDL-C，并且比中脂联素组和高脂联素组的个体表现出更多的MetS表型特征。为了确定chemerin和脂联素与MetS及其组分的关系，根据他们的chemerin和脂联素水平将参与者分为四组（高chemerin/高脂联素，高chemerin/低脂联素，低chemerin/高脂联素，或低chemerin/低脂联素）。高chemerin/低脂联素组的参与者与其他三组相比更容易患有血脂异常和MetS（OR：5.79，95%CI：1.00-33.70）。我们的研究结果表明，chemerin和脂联素可能共同参与代谢综合征的发展。
Obesity and metabolic syndrome (MetS) are considered chronic inflammatory states. Chemerin, a novel adipokine, may play an important role in linking MetS and inflammation. We investigated the association of chemerin with inflammatory markers and with characteristics of MetS in apparently healthy overweight and obese adults. We studied 92 adults; 59 men and 33 women whose average body mass index (BMI) was 28.15±5.08 kg/m2. Anthropometric parameters, insulin resistance indices, lipid profiles, and inflammatory markers including high sensitivity C-reactive protein (hsCRP), pentraxin 3 (PTX3), adiponectin, and chemerin were measured. Controlling for age, gender, and BMI, serum chemerin level was positively correlated with body fat and serum triglyceride, and negatively correlated with adiponectin and high density lipoprotein cholesterol (HDL- C), and was not correlated with altered hsCRP or PTX3 levels. Among the low, moderate and high chemerin groups, high chemerin individuals are more likely to have lower HDL-C. Conversely, individuals in the low adiponectin group are more likely to have lower HDL-C and show more MetS phenotypic traits than moderate and high adiponectin subjects. To determine the relationships of chemerin and adiponectin to MetS and its components, participants were stratified into four groups based on their chemerin and adiponectin levels (high chemerin/high adiponectin, high chemerin/low adiponectin, low chemerin/high adiponectin, or low chemerin/low adiponectin). Participants who were in the high chemerin/low adiponectin group more likely to have dyslipidemia and MetS (OR: 5.79, 95% CI:1.00–33.70) compared to the other three group. Our findings suggest that chemerin and adiponectin may reciprocally participate in the development of MetS.
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