Brain functional activation and first mood episode in youth at risk for bipolar disorder.
Brain functional activation and first mood episode in youth at risk for bipolar disorder.
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有双相情感障碍风险的青少年的大脑功能激活和首次情绪发作。
DOI：
10.1016/j.jad.2023.03.025
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发表时间：
2023
影响因子：
6.6
通讯作者：
DelBello,MelissaP
中科院分区：
文献类型：
--
作者：
Nery,FabianoG;Welge,JeffreyA;Fleck,David;Weber,Wade;Patino,LRodrigo;Strawn,JeffreyR;Adler,CalebM;Strakowski,StephenM;DelBello,MelissaP
背景为了确定前驱情绪障碍的生物标志物，我们检查了有双相情感障碍家族风险的儿童和青少年的功能性大脑激活。方法患有 I 型双相情感障碍的父母的后代（高危青少年；N = 115，平均±标准差年龄：13.6 ± 2.7；54% 女孩）和健康父母的分组匹配后代（健康对照；N = 58，平均±标准差年龄： 14.2 ± 3.0；53% 女孩）在执行带有情绪和中性干扰的连续表演任务时接受了功能性磁共振成像。在基线时，高危青少年没有情绪发作或精神病史。对受试者进行纵向跟踪，直到出现第一次情绪发作或失访。我们进行了标准的事件相关感兴趣区域 (ROI) 分析，以比较各组之间和生存分析中基线时的大脑激活情况。结果在基线时，高危青少年的右腹外侧前额叶皮层 (VLPFC) 对情绪干扰因素的激活减少 (p= 0.04)。其他 ROI 的激活没有显着改变，包括左侧 VLPFC、双侧杏仁核、尾状核或壳核。在那些在随访期间首次出现情绪发作的高危青少年中（n = 17），基线右侧 VLPFC、右侧尾状核和右壳核激活的增加预测了情绪发作的发生。局限性转换者的样本大小、随访丢失以及统计比较的数量。结论我们发现了初步证据，表明右侧 VLPFC 激活的减少可能是高危青少年情绪障碍风险或恢复能力的标志。相反，右侧 VLPFC、尾状核和壳核的激活增加可能表明其首次情绪发作后期发生的风险增加。
BackgroundIn order to identify biomarkers of prodromal mood disorders, we examined functional brain activation in children and adolescent at familial risk for bipolar disorder.MethodsOffspring of parents with bipolar I disorder (at-risk youth; N = 115, mean ± SD age: 13.6 ± 2.7; 54 % girls) and group-matched offspring of healthy parents (healthy controls; N = 58, mean ± SD age: 14.2 ± 3.0; 53 % girls) underwent functional magnetic resonance imaging while performing a continuous performance task with emotional and neutral distracters. At baseline, at-risk youth had no history of mood episodes or psychotic disorders. Subjects were followed longitudinally until developing their first mood episode or being lost to follow-up. Standard event-related region-of-interest (ROI) analyses were performed to compare brain activation at baseline between groups and in survival analyses.ResultsAt baseline, at-risk youth exhibited reduced activation to emotional distracters in the right ventrolateral prefrontal cortex (VLPFC) (p= 0.04). Activation was not significantly altered in additional ROIs, including left VLPFC, bilateral amygdala, caudate, or putamen. In those at-risk youth who developed their first mood episode during follow-up (n = 17), baseline increased activation in right VLPFC, right caudate, and right putamen activation predicted the development of a mood episode.LimitationsSample size of converters, loss to follow-up, and number of statistical comparisons.ConclusionsWe found preliminary evidence that a reduced activation in right VLPFC might be a marker of risk for or resilience to mood disorders in at-risk youth. Conversely, an increased activation in the right VLPFC, caudate, and putamen might indicate an increased risk for the later development of their first mood episode.
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影响因子：
--
作者：
Nurnberger JI Jr;McInnis M;Reich W;Kastelic E;Wilcox HC;Glowinski A;Mitchell P;Fisher C;Erpe M;Gershon ES;Berrettini W;Laite G;Schweitzer R;Rhoadarmer K;Coleman VV;Cai X;Azzouz F;Liu H;Kamali M;Brucksch C;Monahan PO
通讯作者：
Monahan PO
对有患双相情感障碍风险的焦虑青少年进行正念认知治疗前后的神经功能。
影响因子：
1.9
作者：
Strawn,JeffreyR;Cotton,Sian;Luberto,ChristinaM;Patino,LRodrigo;Stahl,LaurenA;Weber,WadeA;Eliassen,JamesC;Sears,Richard;DelBello,MelissaP
通讯作者：
DelBello,MelissaP
DOI：
10.1097/00004583-200104000-00014
发表时间：
2001-04-01
影响因子：
13.3
作者：
Geller, B;Zimerman, B;Soutullo, C
通讯作者：
Soutullo, C
DOI：
10.1006/cbmr.1996.0014
发表时间：
1996-06-01
期刊：
COMPUTERS AND BIOMEDICAL RESEARCH
影响因子：
--
作者：
Cox, RW
通讯作者：
Cox, RW
DOI：
10.1176/appi.ajp.2015.15040414
发表时间：
2016-07-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Hafeman DM;Merranko J;Axelson D;Goldstein BI;Goldstein T;Monk K;Hickey MB;Sakolsky D;Diler R;Iyengar S;Brent D;Kupfer D;Birmaher B
通讯作者：
Birmaher B