Neural Function Before and After Mindfulness-Based Cognitive Therapy in Anxious Adolescents at Risk for Developing Bipolar Disorder.
Neural Function Before and After Mindfulness-Based Cognitive Therapy in Anxious Adolescents at Risk for Developing Bipolar Disorder.
复制标题
对有患双相情感障碍风险的焦虑青少年进行正念认知治疗前后的神经功能。
DOI：
10.1089/cap.2015.0054
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发表时间：
2016
影响因子：
1.9
通讯作者：
DelBello,MelissaP
中科院分区：
文献类型：
--
作者：
Strawn,JeffreyR;Cotton,Sian;Luberto,ChristinaM;Patino,LRodrigo;Stahl,LaurenA;Weber,WadeA;Eliassen,JamesC;Sears,Richard;DelBello,MelissaP
目的：探讨正念认知疗法对青少年广泛性、社会性和/或分离性焦虑症儿童双相情感障碍的神经生理学影响。方法：9例广泛性、社会性和/或分离性焦虑症青少年(平均年龄：13 ± 2岁)和1例双相情感和中性干扰物(CPT-END)持续加工任务的父母在接受正念认知疗法12周前后进行功能磁共振成像检查。结果：正念认知疗法与双侧岛叶、豆状核、而焦虑的减少与观看情绪刺激时双侧脑岛和前扣带回的激活变化相关(p<； 0.005，未校正；p<； 0.005已校正；簇大小，37个体素)。结论：在有双相情感障碍家族史的焦虑青年中，MBCT-C治疗与大脑结构的激活有关，这些结构抑制了内部感觉和内部刺激的处理，而这种治疗表面上改善了这些功能。
Objective:We sought to evaluate the neurophysiology of mindfulness-based cognitive therapy for children (MBCT-C) in youth with generalized, social, and/or separation anxiety disorder who were at risk for developing bipolar disorder.Methods:Nine youth (mean age: 13 ± 2 years) with a generalized, social, and/or separation anxiety disorder and a parent with bipolar disorder completed functional magnetic resonance imaging (fMRI) while performing a continuous processing task with emotional and neutral distractors (CPT-END) prior to and following 12 weeks of MBCT-C.Results:MBCT-C was associated with increases in activation of the bilateral insula, lentiform nucleus, and thalamus, as well as the left anterior cingulate while viewing emotional stimuli during the CPT-END, and decreases in anxiety were correlated with change in activation in the bilateral insula and anterior cingulate during the viewing of emotional stimuli (p< 0.05, uncorrected;p< 0.005 corrected; cluster size, 37 voxels).Conclusions:MBCT-C treatment in anxious youth with a familial history of bipolar disorder is associated with increased activation of brain structures that subserve interoception and the processing of internal stimuli—functions that are ostensibly improved by this treatment.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
4.2
作者：
Goldin, Philippe R.;Gross, James J.
通讯作者：
Gross, James J.
影响因子：
5.9
作者：
Hofmann, Stefan G.;Sawyer, Alice T.;Witt, Ashley A.;Oh, Diana
通讯作者：
Oh, Diana
影响因子：
1.7
作者：
Beesdo, Katja;Knappe, Susanne;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
DOI：
--
发表时间：
2011
期刊：
Paediatric drugs
影响因子：
--
作者：
M. Goldsmith;Manpreet K. Singh;K. Chang
通讯作者：
K. Chang