Peptide growth factors and proto-oncogenes in mammalian conceptus development.
Peptide growth factors and proto-oncogenes in mammalian conceptus development.
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哺乳动物孕体发育中的肽生长因子和原癌基因。
DOI：
10.1095/biolreprod44.1.1
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发表时间：
1991
影响因子：
3.6
通讯作者：
Simmen,RC
中科院分区：
文献类型：
--
作者：
Simmen,FA;Simmen,RC
哺乳动物孕体（胚胎和相关膜）在子宫内的发育是细胞活动的极其复杂的程序化编排，包括增殖、分化、迁移和死亡。孕体发育失败是人类和动物生殖中的一个重要问题，尽管尚未得到很好的理解。最终需要增加对这些事件中的分子和细胞过程的理解，以确定发育失败的机制。肽生长因子、其相关蛋白（载体蛋白和膜受体）和原癌基因（逆转录病毒致癌蛋白的正常细胞对应物）密切参与正常和异常细胞生长调节。本文重点介绍了最近的工作，这表明这些蛋白质的参与在围着床期的孕体生长和子宫-孕体相互作用的关键方面。
Development of mammalian conceptuses (embryo and associated membranes) in utero is an extremely complex, programmed orchestration of cellular activities that include proliferation, differentiation, migration, and death. Failure of conceptuses to develop is a significant, though not well-understood, problem in human and animal reproduction. Increased understanding of molecular and cellular processes in these events is ultimately required to determine the mechanisms responsible for developmental failures. Peptide growth factors, their associated proteins (carrier proteins and membrane receptors), and proto-oncogenes (the normal, cellular counterparts of retroviral oncogenic proteins) are intimately involved in normal and abnormal cellular growth regulation. This paper highlights recent work which suggests the involvement of these proteins in critical aspects of conceptus growth and uterine-conceptus interactions during the peri-implantation period.
影响因子：
56.9
作者：
SOKOL, S;WONG, GG;MELTON, DA
通讯作者：
MELTON, DA