Stimuli-Responsive Materials for Controlled Release of Theranostic Agents.
Stimuli-Responsive Materials for Controlled Release of Theranostic Agents.
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DOI：
10.1002/adfm.201400279
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发表时间：
2014-07-16
影响因子：
19
通讯作者：
Xia Y
中科院分区：
文献类型：
--
作者：
Wang Y;Shim MS;Levinson NS;Sung HW;Xia Y
刺激响应材料之所以这样命名，是因为它们可以改变其物理化学性质和/或结构构象，以响应特定的刺激。刺激可以是内部的，例如目标细胞/组织中的生理或病理变化，也可以是外部的，例如光学和超声波辐射。近年来，这些材料在生物医学应用中获得了越来越多的兴趣，因为它们具有响应特定刺激而在空间和时间上控制治疗药物释放的潜力。本文重点介绍了这类材料发展的几个最新进展，重点介绍了它们的分子设计和配方。还将探索刺激响应材料的未来，包括与分子成像探针和靶向部分的结合，这可以实现对特定疾病的同时诊断和治疗，以及对多种刺激的多功能和响应性，所有这些都对克服内在的生物障碍和提高临床生存能力至关重要。
Stimuli-responsive materials are so named because they can alter their physicochemical properties and/or structural conformations in response to specific stimuli. The stimuli can be internal, such as physiological or pathological variations in the target cells/tissues, or external, such as optical and ultrasound radiations. In recent years, these materials have gained increasing interest in biomedical applications due to their potential for spatially and temporally controlled release of theranostic agents in response to the specific stimuli. This article highlights several recent advances in the development of such materials, with a focus on their molecular designs and formulations. The future of stimuli-responsive materials will also be explored, including combination with molecular imaging probes and targeting moieties, which could enable simultaneous diagnosis and treatment of a specific disease, as well as multi-functionality and responsiveness to multiple stimuli, all important in overcoming intrinsic biological barriers and increasing clinical viability.
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
Almutairi, Adah
影响因子：
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作者：
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