A temperature-sensitive drug release system based on phase-change materials.
A temperature-sensitive drug release system based on phase-change materials.
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DOI：
10.1002/anie.201004057
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发表时间：
2010-10-18
影响因子：
16.6
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Choi, Sung-Wook;Zhang, Yu;Xia, Younan
相变材料（PCMs），包括熔点为38 - 39°C的1 - 十四醇和熔点为43 - 46°C的十二酸，被用作热敏材料来展示一种新的温度调控药物释放系统。在这种方法中，含有异硫氰酸荧光素 - 葡聚糖（FITC - dextran）的胶体颗粒被嵌入PCM基质中，并加工成球体或棒状。当温度低于PCM的熔点时，由于PCM的疏水性，没有异硫氰酸荧光素 - 葡聚糖的释放。当温度升高超过熔点时，PCM开始熔化，包封的颗粒渗出，最终异硫氰酸荧光素 - 葡聚糖从胶体颗粒中释放出来。通过使用由在水中具有不同溶解性的明胶、壳聚糖和聚（乳酸 - 羟基乙酸）制成的胶体颗粒，我们可以控制异硫氰酸荧光素 - 葡聚糖的释放模式。我们还通过将两种不同的PCMs整合到同一装置中展示了一种双重温度调控药物释放系统。作为一个吸引人的特点，我们可以通过明智地选择PCMs和用于胶体颗粒的材料的不同组合，轻松改变药物的起始温度和释放模式。
Phase-change materials (PCMs), including 1-tetradecanol with a melting point at 38–39 °C and dodecanoic acid with a melting point at 43–46 °C were exploited as thermosensitive materials to demonstrate a new temperature-regulated drug release system. In this approach, colloidal particles containing FITC-dextran were embedded in the PCM matrix and processed as spheres or rods. When temperature was below the melting point of the PCM, there was no release of FITC-dextran due to the hydrophobic nature of the PCM. As the temperature was increased beyond the melting point, the PCM began to melt, the encapsulated particles leached out, and eventually FITC-dextran was released from the colloidal particles. By using colloidal particles made of gelatin, chitosan, and poly(lactic-co-glycolic acid) that have different solubility in water, we could manipulate the release pattern of FITC-dextran. We also demonstrated a dual temperature-regulated drug release system by incorporating two different PCMs into the same device. As an attractive feature, we could easily alter the initiation temperature and release pattern of drugs by judiciously selecting different combinations of PCMs and materials for the colloidal particles.
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影响因子：
5.8
作者：
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通讯作者：
Song, Soo-Chang
DOI：
10.1016/0964-8305(94)90012-4
发表时间：
1994-01-01
影响因子：
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作者：
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通讯作者：
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