Risk factors for interstitial lung disease: a 9-year Nationwide population-based study.
Risk factors for interstitial lung disease: a 9-year Nationwide population-based study.
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DOI：
10.1186/s12890-018-0660-2
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发表时间：
2018-06-04
影响因子：
3.1
通讯作者：
Lee CW
中科院分区：
文献类型：
--
作者：
Choi WI;Dauti S;Kim HJ;Park SH;Park JS;Lee CW
了解与间质性肺疾病发生相关的危险因素对了解间质性肺疾病的发病机制以及预防具有重要作用。我们的目的是确定间质性肺病发展的独立危险因素。这是一项回顾性队列研究，具有全国范围内基于人群的9年纵向数据。我们选择的受试者在进入队列时年龄> 40岁，并有自我报告的吸烟史。根据国际疾病分类编码选择病例。对312，519例受试者队列进行了随访，直至2013年12月。我们使用考克斯回归分析来计算间质性肺疾病发展的风险比（HR）。在9年期间，312，519名受试者中的1972年发生了间质性肺病。吸烟（HR：1.2; 95%置信区间[CI]：1.1-1.4）、丙型肝炎（HR：1.6; 95% CI：1.1-2.3）、结核病史（HR：1.5; 95% CI：1.1-1.9）、肺炎史（HR：1.6; 95% CI：1.3-2.0）和慢性阻塞性肺疾病（HR：1.8; 95% CI：1.6-2.1），男性（HR：1.9; 95% CI：1.7-2.1）与间质性肺病的发生显著相关。间质性肺病的风险随着年龄的增长而增加，70岁以上人群的风险是40岁人群的6.9倍（95%CI：5.9-8.0）。吸烟、丙型肝炎、结核病史、肺炎史、慢性阻塞性肺疾病、男性和年龄较大与间质性肺疾病的发生显著相关。
Understanding the risk factors that are associated with the development of interstitial lung disease might have an important role in understanding the pathogenetic mechanism of interstitial lung disease as well as prevention. We aimed to determine independent risk factors of interstitial lung disease development. This was a retrospective cohort study with nationwide population-based 9-year longitudinal data. We selected subjects who were aged > 40 years at cohort entry and with a self-reported history of cigarette smoking. Cases were selected based on International Classification of Diseases codes. A cohort of 312,519 subjects were followed until December 2013. We used Cox regression analysis to calculate the hazard ratios (HRs) for interstitial lung disease development. Interstitial lung disease developed in 1972 of the 312,519 subjects during the 9-year period. Smoking (HR: 1.2; 95% confidence interval [CI]: 1.1–1.4), hepatitis C (HR: 1.6; 95% CI: 1.1–2.3), history of tuberculosis (HR: 1.5; 95% CI: 1.1–1.9), history of pneumonia (HR: 1.6; 95% CI: 1.3–2.0), and chronic obstructive pulmonary disease (HR: 1.8; 95% CI: 1.6–2.1), men (HR: 1.9; 95% CI: 1.7–2.1) were significantly associated with the development of interstitial lung disease. The risk of interstitial lung disease development increases with age, and the risk was 6.9 times higher (95% CI: 5.9–8.0) in those aged over 70 than in their forties. Smoking, hepatitis C, history of tuberculosis, history of pneumonia, chronic obstructive pulmonary disease, male sex, and older age were significantly associated with interstitial lung disease development.
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影响因子：
3.3
作者：
Katzenstein, Anna-Luise A.;Mukhopadhyay, Sanjay;Dexter, Elizabeth
通讯作者：
Dexter, Elizabeth
影响因子：
12.7
作者：
Idilman, R;Çetinkaya, H;Dökmeci, A
通讯作者：
Dökmeci, A
影响因子：
3.1
作者：
Inomata M;Ikushima S;Awano N;Kondoh K;Satake K;Masuo M;Kusunoki Y;Moriya A;Kamiya H;Ando T;Yanagawa N;Kumasaka T;Ogura T;Sakai F;Azuma A;Gemma A;Takemura T
通讯作者：
Takemura T
DOI：
10.1056/nejmoa1216076
发表时间：
2013-06-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hunninghake GM;Hatabu H;Okajima Y;Gao W;Dupuis J;Latourelle JC;Nishino M;Araki T;Zazueta OE;Kurugol S;Ross JC;San José Estépar R;Murphy E;Steele MP;Loyd JE;Schwarz MI;Fingerlin TE;Rosas IO;Washko GR;O'Connor GT;Schwartz DA
通讯作者：
Schwartz DA
影响因子：
7.7
作者：
Lee, Juneyoung;Lee, Ji Sung;Kim, KeeWhan
通讯作者：
Kim, KeeWhan