dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence.
dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence.
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dbLGL：在线白血病基因和文献数据库，用于对成人和儿童白血病遗传学与文献证据进行回顾性比较
DOI：
10.1093/database/bay062
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Qu H
中科院分区：
文献类型：
--
作者：
Liu Y;Luo M;Jin Z;Zhao M;Qu H
摘要 白血病是一组起源于骨髓和其他造血器官的未成熟或异常白细胞数量增加的癌症。针对不同亚型的差异诊断生物标志物的开发很大程度上取决于对与白血病相关基因相关的生物学途径和调控机制的了解。不幸的是，迄今为止已确定的与白血病相关的基因分散在数千项已发表的研究中，而且对于成人和儿童白血病之间关于各种亚型的致病基因突变和遗传机制的差异，还没有系统的总结。在本研究中，我们对小规模实验中报道的易感基因进行了系统的文献综述，并建立了一个包含总共1805个白血病相关基因的在线基因数据库，可在http://soft.bioinfo-minzhao.org/lgl/获取。我们对四种主要亚型以及成人和儿童病例之间的基因进行比较，确定了许多与患者生存相关的潜在基因。这些精选基因可以满足进一步整合白血病相关低频突变基因基因组学筛查日益增长的需求。数据库网址：http://soft.bioinfo-minzhao.org/lgl/
Abstract Leukemia is a group of cancers with increased numbers of immature or abnormal leucocytes that originated in the bone marrow and other blood-forming organs. The development of differentially diagnostic biomarkers for different subtypes largely depends on understanding the biological pathways and regulatory mechanisms associated with leukemia-implicated genes. Unfortunately, the leukemia-implicated genes that have been identified thus far are scattered among thousands of published studies, and no systematic summary of the differences between adult and childhood leukemia exists with regard to the causative genetic mutations and genetic mechanisms of the various subtypes. In this study, we performed a systematic literature review of those susceptibility genes reported in small-scale experiments and built an online gene database containing a total of 1805 leukemia-associated genes, available at http://soft.bioinfo-minzhao.org/lgl/. Our comparison of genes from the four primary subtypes and between adult and childhood cases identified a number of potential genes related to patient survival. These curated genes can satisfy a growing demand for further integrating genomics screening for leukemia-associated low-frequency mutated genes. Database URL: http://soft.bioinfo-minzhao.org/lgl/
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影响因子：
9.2
作者：
Liang J;Wu YL;Chen BJ;Zhang W;Tanaka Y;Sugiyama H
通讯作者：
Sugiyama H
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影响因子：
14.9
作者：
Zhang HM;Liu T;Liu CJ;Song S;Zhang X;Liu W;Jia H;Xue Y;Guo AY
通讯作者：
Guo AY
影响因子：
20.3
作者：
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通讯作者：
Grant, Steven
影响因子：
--
作者：
Elkholi, Rana;Floros, Konstantinos V;Chipuk, Jerry E
通讯作者：
Chipuk, Jerry E
影响因子：
15.9
作者：
Molenaar, Remco J.;Verbaan, Dagmar;Bleeker, Fonnet E.
通讯作者：
Bleeker, Fonnet E.