Well-temperate phage: optimal bet-hedging against local environmental collapses.
Well-temperate phage: optimal bet-hedging against local environmental collapses.
复制标题
DOI：
10.1038/srep10523
复制
发表时间：
2015-06-02
影响因子：
4.6
通讯作者：
Sneppen K
中科院分区：
文献类型：
--
作者：
Maslov S;Sneppen K
在感染细菌宿主后，温氏杆菌必须在溶原性和溶解性发育策略之间做出选择。在这里，我们应用博弈论的赌注对冲策略引入凯利推导出的最佳溶原性分数的总人口的的的功能的频率和强度的环境衰退影响的溶解亚群的。从我们的标题“温和”噬菌体的特点是最好的长期人口增长率。我们表明，它是实现时，溶原化频率约等于裂解人口崩溃的概率。我们进一步预测系统的环境，生态和生物物理参数分离的地区，这种温和的策略是最佳的纯毒力或休眠（纯溶原性）的策略占主导地位的尖锐的边界的存在。我们发现，毒性策略的效果最好的宿主的多样性，并获得多个独立的环境可达扩散的病毒。相反，在频繁和严重的时间衰退的环境中，逐渐更温和甚至休眠的策略是有利的。
Upon infection of their bacterial hosts temperate phages must chose between lysogenic and lytic developmental strategies. Here we apply the game-theoretic bet-hedging strategy introduced by Kelly to derive the optimal lysogenic fraction of the total population of phages as a function of frequency and intensity of environmental downturns affecting the lytic subpopulation. “Well-temperate” phage from our title is characterized by the best long-term population growth rate. We show that it is realized when the lysogenization frequency is approximately equal to the probability of lytic population collapse. We further predict the existence of sharp boundaries in system’s environmental, ecological, and biophysical parameters separating the regions where this temperate strategy is optimal from those dominated by purely virulent or dormant (purely lysogenic) strategies. We show that the virulent strategy works best for phages with large diversity of hosts, and access to multiple independent environments reachable by diffusion. Conversely, progressively more temperate or even dormant strategies are favored in the environments, that are subject to frequent and severe temporal downturns.
登录
查看更多内容
影响因子：
2.6
作者：
Jessup, Christine A.;Forde, Samantha E.
通讯作者：
Forde, Samantha E.
影响因子：
3.8
作者：
PAYNTER, MJB;BUNGAY, HR
通讯作者：
BUNGAY, HR
影响因子：
64.8
作者：
BERGH, O;BORSHEIM, KY;HELDAL, M
通讯作者：
HELDAL, M
影响因子：
2.9
作者：
LEVIN, BR;STEWART, FM;CHAO, L
通讯作者：
CHAO, L
影响因子：
1.4
作者：
BULMER, MG
通讯作者：
BULMER, MG