Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence.
Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence.
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DOI：
10.1126/sciadv.add8687
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发表时间：
2023-01-13
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
High relapse rate is a key feature of opioid addiction. In humans, abstinence is often voluntary due to negative consequences of opioid seeking. To mimic this human condition, we recently introduced a rat model of incubation of oxycodone craving after electric barrier–induced voluntary abstinence. Incubation of drug craving refers to time-dependent increases in drug seeking after cessation of drug self-administration. Here, we used the activity marker Fos, muscimol-baclofen (GABAa + GABAb receptor agonists) global inactivation, Daun02-selective inactivation of putative relapse-associated neuronal ensembles, and fluorescence-activated cell sorting of Fos-positive cells and quantitative polymerase chain reaction to demonstrate a key role of vSub neuronal ensembles in incubation of oxycodone craving after voluntary abstinence, but not homecage forced abstinence. We also used a longitudinal functional magnetic resonance imaging method and showed that functional connectivity changes in vSub-related circuits predict opioid relapse after abstinence induced by adverse consequences of opioid seeking. A key role of the ventral subiculum in incubation of opioid craving after abstinence induced by adverse consequences.
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DOI：
10.1523/jneurosci.1914-12.2012
发表时间：
2012-08-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fanous S;Goldart EM;Theberge FR;Bossert JM;Shaham Y;Hope BT
通讯作者：
Hope BT
影响因子：
10.6
作者：
Caprioli D;Venniro M;Zeric T;Li X;Adhikary S;Madangopal R;Marchant NJ;Lucantonio F;Schoenbaum G;Bossert JM;Shaham Y
通讯作者：
Shaham Y
影响因子：
10.6
作者：
Adinoff B;Gu H;Merrick C;McHugh M;Jeon-Slaughter H;Lu H;Yang Y;Stein EA
通讯作者：
Stein EA
影响因子：
3.3
作者：
Blackwood, Christopher A.;Leary, Michael;Cadet, Jean Lud
通讯作者：
Cadet, Jean Lud
影响因子：
25
作者：
Bossert, Jennifer M.;Stern, Anna L.;Theberge, Florence R. M.;Cifani, Carlo;Koya, Eisuke;Hope, Bruce T.;Shaham, Yavin
通讯作者：
Shaham, Yavin