Basal Hippocampal Activity and Its Functional Connectivity Predicts Cocaine Relapse.
Basal Hippocampal Activity and Its Functional Connectivity Predicts Cocaine Relapse.
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DOI：
10.1016/j.biopsych.2014.12.027
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发表时间：
2015-10-01
影响因子：
10.6
通讯作者：
Stein EA
中科院分区：
文献类型：
--
作者：
Adinoff B;Gu H;Merrick C;McHugh M;Jeon-Slaughter H;Lu H;Yang Y;Stein EA
可卡因引起的神经可塑性变化可能导致复发倾向增加。本研究使用局部脑血流量（rCBF）作为基础神经元活动的标志物，评估了rCBF和相关静息状态功能连接（rsFC）的改变，以前瞻性预测可卡因使用障碍（CUD）治疗后患者的复发。伪连续动脉自旋标记功能磁共振成像和静息血氧水平依赖性功能磁共振成像数据采集在同一个扫描会话与CUD住院治疗出院前禁欲参与者和20名健康匹配的对照组。出院后每周两次评估药物使用情况。复发参与者定义为治疗出院后30天内使用兴奋剂的参与者（n = 22）;早期缓解参与者（n = 18）没有。体素方面，全脑分析显示增强rCBF仅在左侧后海马（pHp）的复发组与早期缓解组和对照组相比。使用此pHp作为种子，在复发与早期缓解亚组中观察到后扣带回皮质（PCC）/楔前叶的rsFC强度增加。总之，增加的pHp rCBF和加强的pHp-PCC rsFC在治疗后30、60和90天预测复发的准确性为75%。在有早期复发风险的CUD参与者中，增加的pHp基础活性和pHp-PCC回路强度可能反映了对可卡因线索的反应性增加和持续的可卡因相关反刍的倾向。使过度激活的大脑区域静音和使失调的神经回路脱钩的机制可能被证明对预防CUD患者复发有用。
Cocaine-induced neuroplastic changes may result in a heightened propensity for relapse. Using regional cerebral blood flow (rCBF) as a marker of basal neuronal activity, this study assessed alterations in rCBF and related resting state functional connectivity (rsFC) to prospectively predict relapse in patients following treatment for cocaine use disorder (CUD). Pseudocontinuous arterial spin labeling functional magnetic resonance imaging and resting blood oxygen level-dependent functional magnetic resonance imaging data were acquired in the same scan session in abstinent participants with CUD before residential treatment discharge and in 20 healthy matched control subjects. Substance use was assessed twice weekly following discharge. Relapsed participants were defined as those who used stimulants within 30 days following treatment discharge (n = 22); early remission participants (n = 18) did not. Voxel-wise, whole-brain analysis revealed enhanced rCBF only in the left posterior hippocampus (pHp) in the relapsed group compared with the early remission and control groups. Using this pHp as a seed, increased rsFC strength with the posterior cingulate cortex (PCC)/precuneus was seen in the relapsed versus early remission subgroups. Together, both increased pHp rCBF and strengthened pHp-PCC rsFC predicted relapse with 75% accuracy at 30, 60, and 90 days following treatment. In CUD participants at risk of early relapse, increased pHp basal activity and pHp-PCC circuit strength may reflect the propensity for heightened reactivity to cocaine cues and persistent cocaine-related ruminations. Mechanisms to mute hyperactivated brain regions and delink dysregulated neural circuits may prove useful to prevent relapse in patients with CUD.
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影响因子：
5.7
作者：
Geng X;Christensen GE;Gu H;Ross TJ;Yang Y
通讯作者：
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作者：
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通讯作者：
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