Steroids plus antiviral agents are more effective than steroids alone in the treatment of severe Bell's palsy patients over 40 years of age.
Steroids plus antiviral agents are more effective than steroids alone in the treatment of severe Bell's palsy patients over 40 years of age.
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在治疗40岁以上的严重贝尔的麻痹患者方面，类固醇和抗病毒剂比单独的类固醇更有效。
DOI：
10.1177/20587384211042124
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发表时间：
2021-01
影响因子：
3.5
通讯作者：
Yeo SG
中科院分区：
文献类型：
--
作者：
Kim Y;Doo JG;Chon J;Lee JH;Jung J;Lee JM;Kim SH;Yeo SG
类固醇和抗病毒药物联合治疗贝尔麻痹的有效性尚不清楚。本研究评估了联合治疗对严重贝尔麻痹患者的治疗效果，并评估了联合治疗比单独使用类固醇更有效的特定条件。从2005年1月到2019年12月，回顾性审查了访问庆熙大学医院的1710名贝尔麻痹患者的记录。其中，335例（19.6%）患者被诊断为重度贝尔麻痹，162例患者单独使用类固醇治疗，173例患者使用类固醇和抗病毒药联合治疗。根据年龄、性别、高血压、糖尿病和肥胖，使用House-Brackmann（H-B）分级评估治疗结局。与单独使用类固醇相比，使用类固醇和抗病毒药物联合治疗的重度贝尔麻痹患者的良好恢复率显著更高（78.0% vs. 66.7%，p = 0.020）。亚组分析显示，在年龄≥40岁的患者（77.5% vs. 64.1%，p = 0.023）以及无高血压（75.8% vs. 63.3%，p = 0.044）和糖尿病（79.7% vs. 65.5%，p = 0.007）的患者中，联合治疗的恢复率显著高于类固醇单药治疗。在重度贝尔麻痹患者中，类固醇和抗病毒剂联合治疗比单独使用类固醇治疗的有利恢复率显著更高。在年龄≥40岁的患者和无高血压和糖尿病的患者中，联合治疗比单用类固醇更有效。
The effectiveness of the combination of steroids and antiviral agents in the treatment of Bell’s palsy remains unclear. This study evaluated the therapeutic effect of combination therapy in severe Bell’s palsy patients and assesses specific conditions under which combination therapy is more effective than steroids alone. From January 2005 to December 2019, the records of 1710 Bell’s palsy patients who visited Kyung Hee University Hospital were reviewed retrospectively. Of these, 335 (19.6%) patients were diagnosed with severe Bell’s palsy, with 162 patients treated with steroids alone and 173 patients treated with combinations of steroids and antiviral agents. The outcomes of treatment were assessed using the House–Brackmann (H-B) grade according to age, sex, hypertension, diabetes, and obesity. The favorable recovery rate was significantly higher in severe Bell’s palsy patients who were treated with combinations of steroids and antiviral agents than with steroids alone (78.0% vs. 66.7%, p = 0.020). Subgroup analysis showed that combination therapy resulted in significantly higher recovery rates than steroids alone in patients aged ≥40 years (77.5% vs. 64.1%, p = 0.023) and in those without hypertension (75.8% vs. 63.3%, p = 0.044) and diabetes (79.7% vs. 65.5%, p = 0.007). Combination therapy with steroids and antiviral agents resulted in significantly higher favorable recovery rates than steroids alone in severe Bell’s palsy patients. Combination therapy was particularly more effective than steroids alone in patients aged ≥40 years and in patients without hypertension and diabetes.
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影响因子：
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作者：
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