A multi-tissue multi-omics analysis reveals distinct kineztics in entrainment of diurnal transcriptomes by inverted feeding.
A multi-tissue multi-omics analysis reveals distinct kineztics in entrainment of diurnal transcriptomes by inverted feeding.
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多组织多组学分析揭示了反向进食夹带昼夜转录组的独特动力学。
DOI：
10.1016/j.isci.2021.102335
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发表时间：
2021-04-23
期刊：
影响因子：
5.8
通讯作者：
Li MD
中科院分区：
文献类型：
--
作者：
Xin H;Deng F;Zhou M;Huang R;Ma X;Tian H;Tan Y;Chen X;Deng D;Shui G;Zhang Z;Li MD
进食时间使新陈代谢和生理的昼夜节律同步。倒置摄食可以使周围的生物钟与位于视交叉上核的中央钟分离。然而，外周组织中昼夜节律代谢和生理变化与倒食有关的系统范围的变化在很大程度上仍未被探索。在这里，我们对小鼠外周组织中的转录物和代谢物进行了24小时的全球图谱分析，以研究倒置摄食过程中的过渡动力学，发现倒置摄食对昼夜转录物的相携带具有明显的动力学特征，从脂肪组织(几乎完全夹带)、肝脏、肾脏到心脏。组织时钟的相位动力学与转录本的相位动力学相跟踪，并由与光相关的提示进行门控。对转录物和代谢物的综合分析表明，尽管心脏时钟对摄食的携带具有缓慢的动力学/抵抗力，但脂肪酸氧化完全导致了心脏的反转摄食。这个多组学资源定义了外周组织中倒摄食的昼夜节律特征(www.CircaMetDB.org.cn)。小鼠外周组织中食物夹带的多组学分析倒置摄食节律携带具有不同动力学相的日间转录物组织时钟的动力学由恒光心脏代谢夹带到快速摄食与缓慢的心脏时钟动力学动物生理学；系统生物学；代谢组学；转录组学
Time of eating synchronizes circadian rhythms of metabolism and physiology. Inverted feeding can uncouple peripheral circadian clocks from the central clock located in the suprachiasmatic nucleus. However, system-wide changes of circadian metabolism and physiology entrained to inverted feeding in peripheral tissues remain largely unexplored. Here, we performed a 24-h global profiling of transcripts and metabolites in mouse peripheral tissues to study the transition kinetics during inverted feeding, and revealed distinct kinetics in phase entrainment of diurnal transcriptomes by inverted feeding, which graded from fat tissue (near-completely entrained), liver, kidney, to heart. Phase kinetics of tissue clocks tracked with those of transcriptomes and were gated by light-related cues. Integrated analysis of transcripts and metabolites demonstrated that fatty acid oxidation entrained completely to inverted feeding in heart despite the slow kinetics/resistance of the heart clock to entrainment by feeding. This multi-omics resource defines circadian signatures of inverted feeding in peripheral tissues (www.CircaMetDB.org.cn). A multi-omics analysis of food entrainment in mouse peripheral tissues Inverted feeding rhythm entrains diurnal transcriptomes with distinct kinetics Phase kinetics of tissue clocks is conditioned by constant light Cardiac metabolism entrains to feeding fast with slow kinetics of the heart clock Animal Physiology ; Systems Biology ; Metabolomics ; Transcriptomics
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DOI：
10.1523/jneurosci.2191-08.2008
发表时间：
2008-11-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chen R;Seo DO;Bell E;von Gall C;Lee C
通讯作者：
Lee C
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
昼夜主义代谢的地图集揭示了时钟之间全系统的协调和通信。
影响因子：
64.5
作者：
Dyar KA;Lutter D;Artati A;Ceglia NJ;Liu Y;Armenta D;Jastroch M;Schneider S;de Mateo S;Cervantes M;Abbondante S;Tognini P;Orozco-Solis R;Kinouchi K;Wang C;Swerdloff R;Nadeef S;Masri S;Magistretti P;Orlando V;Borrelli E;Uhlenhaut NH;Baldi P;Adamski J;Tschöp MH;Eckel-Mahan K;Sassone-Corsi P
通讯作者：
Sassone-Corsi P
影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
Panda S
影响因子：
64.5
作者：
Guan D;Xiong Y;Borck PC;Jang C;Doulias PT;Papazyan R;Fang B;Jiang C;Zhang Y;Briggs ER;Hu W;Steger D;Ischiropoulos H;Rabinowitz JD;Lazar MA
通讯作者：
Lazar MA