Primary structure and biological activity of human brain-derived neurotrophic factor.
Primary structure and biological activity of human brain-derived neurotrophic factor.
复制标题
人脑源性神经营养因子的一级结构和生物活性。
作者：
Arnon Rosenthal;D. Goeddel;Thu Nguyen;E. Martin;Louis E. Burton;A. Shih;G. Laramee;Florian M. Wurm;Anthony J. Mason;K. Nikolics;John W. Winslow
脑源性神经营养因子（BDNF）是一种27-kDa的碱性蛋白质，由与神经生长因子相关的13.5-kD亚基非共价连接而成，由中枢神经系统（CNS）产生。BDNF已显示出促进位于CNS中或与CNS直接连接的神经元的存活，并且可能在调节神经元群体内的细胞数量以满足该投射场的需要方面起作用。本文描述了人BDNF cDNA的一级结构、纯重组人BDNF的生物学活性以及大鼠BDNF的组织分布。BDNF mRNA可以在一些外周组织以及CNS中发现，并且重组人BDNF是初级外周感觉神经元的有效神经营养因子。
Brain-derived neurotrophic factor (BDNF) is a 27-kDa basic protein of noncovalently linked 13.5-kD subunits related to nerve growth factor and is produced by the central nervous system (CNS). BDNF has been shown to promote the survival of neurons located in or directly connected with the CNS and is likely to function in adjusting the cell number within neuronal populations to the need of this projection field. Here we describe the primary structure of a human BDNF cDNA, the biological activities of pure recombinant human BDNF, and the tissue distribution of rat BDNF. BDNF mRNA can be found in some peripheral tissues as well as in the CNS, and recombinant human BDNF is a potent neurotrophic factor for primary peripheral sensory neurons.
影响因子：
56.9
作者：
COWAN, WM;FAWCETT, JW;STANFIELD, BB
通讯作者：
STANFIELD, BB
DOI：
10.1073/pnas.88.3.961
发表时间：
1991-02-01
影响因子：
11.1
作者：
KNUSEL, B;WINSLOW, JW;HEFTI, F
通讯作者：
HEFTI, F