Multi-disciplinary methods to define RNA-protein interactions and regulatory networks.
Multi-disciplinary methods to define RNA-protein interactions and regulatory networks.
复制标题
DOI：
10.1016/j.gde.2013.01.003
复制
发表时间：
2013-02
影响因子：
4
通讯作者：
Tuschl, Thomas
中科院分区：
文献类型：
--
作者：
Ascano, Manuel;Gerstberger, Stefanie;Tuschl, Thomas
包括深度测序和蛋白质质谱仪在内的高通量技术的出现，正在促进获取大量和精确的数据集，以定义转录后调控网络。虽然早期孤立地研究特定RNA-蛋白质相互作用的研究为我们理解组装和处理RNA的分子机器的存在奠定了基础，但最近人们认识到单个RNA-蛋白质相互作用对转录后基因调控的重要性。大量的RNA结合蛋白(RBPs)及其许多RNA靶标直到最近才被实验捕获。在这篇综述中，我们将审查目前多学科的方法来阐明RNA-蛋白质网络及其调控。
The advent of high-throughput technologies including deep-sequencing and protein mass spectrometry is facilitating the acquisition of large and precise data sets towards the definition of post-transcriptional regulatory networks. While early studies that investigated specific RNA-protein interactions in isolation laid the foundation for our understanding of the existence of molecular machines to assemble and process RNAs, there is a more recent appreciation of the importance of individual RNA-protein interactions that contribute to post-transcriptional gene regulation. The multitude of RNA-binding proteins (RBPs) and their many RNA targets has only been captured experimentally in recent times. In this review, we will examine current multidisciplinary approaches towards elucidating RNA-protein networks and their regulation.
登录
查看更多内容
影响因子：
64.5
作者：
Hafner M;Landthaler M;Burger L;Khorshid M;Hausser J;Berninger P;Rothballer A;Ascano M Jr;Jungkamp AC;Munschauer M;Ulrich A;Wardle GS;Dewell S;Zavolan M;Tuschl T
通讯作者：
Tuschl T
影响因子：
5.3
作者：
Buckanovich, RJ;Darnell, RB
通讯作者：
Darnell, RB
影响因子：
16.8
作者：
通讯作者：
--
影响因子：
64.5
作者：
Berg, Michael G.;Singh, Larry N.;Dreyfuss, Gideon
通讯作者：
Dreyfuss, Gideon
影响因子：
82.9
作者：
通讯作者：
--