Genome-wide association uncovers shared genetic effects among personality traits and mood states.
Genome-wide association uncovers shared genetic effects among personality traits and mood states.
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DOI：
10.1002/ajmg.b.32072
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发表时间：
2012-09
影响因子：
2.8
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Luciano, Michelle;Huffman, Jennifer E.;Arias-Vasquez, Alejandro;Vinkhuyzen, Anna A. E.;Middeldorp, Christel M.;Giegling, Ina;Payton, Antony;Davies, Gail;Zgaga, Lina;Janzing, Joost;Ke, Xiayi;Galesloot, Tessel;Hartmann, Annette M.;Ollier, William;Tenesa, Albert;Hayward, Caroline;Verhagen, Maaike;Montgomery, Grant W.;Hottenga, Jouke-Jan;Konte, Bettina;Starr, John M.;Vitart, Veronique;Vos, Pieter E.;Madden, Pamela A. F.;Willemsen, Gonneke;Konnerth, Heike;Horan, Michael A.;Porteous, David J.;Campbell, Harry;Vermeulen, Sita H.;Heath, Andrew C.;Wright, Alan;Polasek, Ozren;Kovacevic, Sanja B.;Hastie, Nicholas D.;Franke, Barbara;Boomsma, Dorret I.;Martin, Nicholas G.;Rujescu, Dan;Wilson, James F.;Buitelaar, Jan;Pendleton, Neil;Rudan, Igor;Deary, Ian J.
人格和心理痛苦的测量是相关的，并表现出遗传协变性。我们对这些性状进行了单变量全基因组SNP(约250万)和基于基因的关联分析，并检查了不同性状结果的重叠，包括使用人格遗传多基因得分对情绪状态进行预测分析。在平均年龄从55岁到79岁的8个欧洲队列(n从546到1338；最大总数n=6268)中收集了神经质、外向以及焦虑、抑郁和一般心理困扰的症状的测量。对队列结果进行Meta分析，并对独立队列(n=527-6032)中最常见的SNPs和基因的相关性进行了跟踪调查。FHIT基因rs1079196与焦虑症状有关联(P=8×10−8)。其他值得注意的关联(P<；6.09×10−6)包括神经质的五个基因(LCE3C、POLR3A、LMAN1L、ULK3、SCAMP2)的SNPs，KIAA0802和一般心理困扰的NOS1基因。抑郁症状和rs7582472(接近MGAT5和NCKAP5)之间的关联在两个独立的样本中重复，但其他重复发现不太一致。基于基因的测试确定了15号染色体上一个与神经质有关的重要基因(跨越五个基因)，该基因在一个独立的队列中复制(P<；0.05)。在SNP关联、重叠和多基因得分预测方面，支持个性和情绪(特别是神经质和抑郁症状)之间的共同遗传效应。单个SNPs的解释方差很小(最高可达1%)，这证实了普通SNPs对人格和相关特质没有中等/较大的影响。
Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (~2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546 to 1 338; maximum total n=6 268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n=527 to 6 032). Suggestive association (P=8×10−8) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P<6.09×10−6) included SNPs in five genes for neuroticism (LCE3C, POLR3A, LMAN1L, ULK3, SCAMP2), KIAA0802 for extraversion, and NOS1 for general psychological distress. An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent. Gene-based tests identified a significant locus on chromosome 15 (spanning five genes) associated with neuroticism which replicated (P<0.05) in an independent cohort. Support for common genetic effects among personality and mood (particularly neuroticism and depressive symptoms) was found in terms of SNP association overlap and polygenic score prediction. The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits.
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影响因子：
9.8
作者：
Liu, Jimmy Z.;Mcrae, Allan F.;Macgregor, Stuart
通讯作者：
Macgregor, Stuart
精神分裂症，躁郁症和抑郁症的跨disor阶层基因组分析。
DOI：
10.1176/appi.ajp.2010.09091335
发表时间：
2010-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Huang J;Perlis RH;Lee PH;Rush AJ;Fava M;Sachs GS;Lieberman J;Hamilton SP;Sullivan P;Sklar P;Purcell S;Smoller JW
通讯作者：
Smoller JW
影响因子：
11
作者：
通讯作者：
--
影响因子：
5
作者：
Johnson, W;McGue, M;Krueger, RF
通讯作者：
Krueger, RF
DOI：
10.1375/13690520460741435
发表时间：
2004-02-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Gillespie, NA;Kirk, KM;Martin, NG
通讯作者：
Martin, NG