An update on microRNAs as colorectal cancer biomarkers: where are we and what's next?
An update on microRNAs as colorectal cancer biomarkers: where are we and what's next?
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DOI：
10.1586/14737159.2014.946907
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发表时间：
2014-11
影响因子：
5.1
通讯作者：
Goel A
中科院分区：
文献类型：
--
作者：
Okugawa Y;Toiyama Y;Goel A
microRNA（miRNA）是一类丰富的内源性小分子非编码RNA，通过转录后调节抑制靶基因的表达。除了在致癌作用中发挥重要的功能作用外，新出现的证据已经证明了miRNA作为稳健的癌症生物标志物的可行性。特别是，最近在体液中发现的miRNA为开发用于癌症治疗的诊断、预后和预测反应的非侵入性生物标志物提供了有吸引力的机会。结直肠癌（CRC）是世界范围内最常见的癌症之一，越来越多的证据为miRNA作为CRC生物标志物的潜在开发提供了令人信服的案例。这篇综述总结了该领域的文献现状，主要集中在miRNA作为CRC治疗的潜在生物标志物的临床意义上，并讨论了即将到来的挑战，以进一步推进这一令人兴奋的领域的“学术研究”到“床边临床护理”的患者患有CRC。
MicroRNAs (miRNA) are abundant classes of small, endogenous non-coding RNAs, which inhibit the expression of target gene via post-transcriptional regulation. In addition to an important functional role miRNAs play in carcinogenesis, emerging evidence has demonstrated the feasibility of miRNAs as robust cancer biomarkers. In particular, the recent discovery of miRNAs in the body fluids provides an attractive opportunity for the development of non-invasive biomarkers for the diagnosis, prognosis and predictive responses to cancer therapy. Colorectal cancer (CRC) is one of the most common cancers worldwide, and accumulating evidence provides a compelling case for the potential exploitation of miRNAs as CRC-biomarkers. This review summarizes the current state of literature in the field, and primarily focuses on the clinical relevance of miRNAs as potential biomarkers for CRC treatment, and discusses the forthcoming challenges to further advance this exciting field of “academic research” into “bedside clinical care” of patients suffering from CRC.
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影响因子：
39.2
作者：
Ahlquist DA;Sargent DJ;Loprinzi CL;Levin TR;Rex DK;Ahnen DJ;Knigge K;Lance MP;Burgart LJ;Hamilton SR;Allison JE;Lawson MJ;Devens ME;Harrington JJ;Hillman SL
通讯作者：
Hillman SL
影响因子：
4.7
作者：
Chen DL;Wang DS;Wu WJ;Zeng ZL;Luo HY;Qiu MZ;Ren C;Zhang DS;Wang ZQ;Wang FH;Li YH;Kang TB;Xu RH
通讯作者：
Xu RH
影响因子：
11.2
作者：
Chen, Hsin-Yi;Lin, Yu-Min;Chen, Ruey-Hwa
通讯作者：
Chen, Ruey-Hwa
影响因子：
37.3
作者：
Bandrés E;Cubedo E;Agirre X;Malumbres R;Zárate R;Ramirez N;Abajo A;Navarro A;Moreno I;Monzó M;García-Foncillas J
通讯作者：
García-Foncillas J
影响因子：
29.4
作者：
Ahlquist, DA;Skoletsky, JE;Shuber, AP
通讯作者：
Shuber, AP