Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial.
Effects of purified anthocyanin supplementation on platelet chemokines in hypocholesterolemic individuals: a randomized controlled trial.
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纯化花青素补充剂对低胆固醇血症个体血小板趋化因子的影响：一项随机对照试验
DOI：
10.1186/s12986-016-0146-2
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发表时间：
2016
影响因子：
4.5
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Zhang X;Zhu Y;Song F;Yao Y;Ya F;Li D;Ling W;Yang Y
越来越明显的是，血小板趋化因子参与动脉粥样硬化的不同方面。本研究的目的是检查长期补充纯化花青素对高胆固醇血症个体血小板趋化因子的影响，并确定血小板趋化因子水平降低与血清脂质和炎症标志物水平的相关性。在这项随机、双盲、安慰剂对照试验中，总共招募了 146 名高胆固醇血症个体，并每天接受 320 毫克纯化花青素 (n = 73) 或安慰剂 (n = 73) 治疗，为期 24 周。补充花青素 24 周显着降低血浆 CXCL7（–12.32% vs. 4.22%，P = 0.001）、CXCL5（–9.95% vs. 1.93%，P = 0.011）、CXCL8（–6.07% vs. 0.66%，与安慰剂相比，P = 0.004）、CXCL12（–8.11% vs. 5.43%，P = 0.023）和 CCL2 水平（–11.63% vs. 12.84%，P = 0.001）。有趣的是，补充花青素24周后，CXCL7和CCL2水平的降低均与血清低密度脂蛋白胆固醇（LDL-C）、高敏C反应蛋白（hsCRP）和白细胞介素1β（IL-1β）水平的降低呈正相关。花青素组中CXCL8水平的降低与高密度脂蛋白胆固醇（HDL-C）水平的升高呈负相关，与可溶性P-选择素（sP-选择素）水平的降低呈正相关。此外，补充花青素后，CXCL12 和肿瘤坏死因子-α (TNF-α) 水平的降低呈正相关。然而，补充花青素后，血浆CXCL4L1、CXCL1、巨噬细胞迁移抑制因子（MIF）和人纤溶酶原激活剂抑制剂1（PAI-1）水平没有显着变化。本研究支持这样的观点，即血小板趋化因子是花青素预防动脉粥样硬化的有希望的靶标。 ChiCTR-TRC-08000240。注册日期：2008 年 12 月 10 日。
It is becoming increasingly evident that platelet chemokines are involved in distinct aspects of atherosclerosis. The aim of this study was to examine the effects of long-term supplementation with purified anthocyanins on platelet chemokines in hypercholesterolemic individuals and to identify correlations of decreased platelet chemokine levels with serum lipid and inflammatory marker levels. A total of 146 hypercholesterolemic individuals were recruited and treated with 320 mg of purified anthocyanins (n = 73) or a placebo (n = 73) daily for 24 weeks in this randomized, double-blind, placebo-controlled trial. Anthocyanin supplementation for 24 weeks significantly decreased the plasma CXCL7 (–12.32% vs. 4.22%, P = 0.001), CXCL5 (–9.95% vs. 1.93%, P = 0.011), CXCL8 (–6.07% vs. 0.66%, P = 0.004), CXCL12 (–8.11% vs. 5.43%, P = 0.023) and CCL2 levels (–11.63% vs. 12.84%, P = 0.001) compared with the placebo. Interestingly, the decreases in the CXCL7 and CCL2 levels were both positively correlated with the decreases in the serum low-density lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein (hsCRP) and interleukin-1β (IL-1β) levels after anthocyanin supplementation for 24 weeks. The decrease in the CXCL8 level was negatively correlated with the increase in the how-density lipoprotein-cholesterol (HDL-C) level and was positively correlated with the decrease in the soluble P-selectin (sP-selectin) level in the anthocyanin group. In addition, a positive correlation was observed between the decreases in the CXCL12 and tumornecrosis factor-α (TNF-α) levels after anthocyanin supplementation. However, the plasma CXCL4L1, CXCL1, macrophage migration inhibitory factor (MIF) and human plasminogen activator inhibitor 1 (PAI-1) levels did not significantly change following anthocyanin supplementation. The present study supports the notion that platelet chemokines are promising targets of anthocyanins in the prevention of atherosclerosis. ChiCTR-TRC-08000240. Registered: 10 December 2008.
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影响因子：
7.3
作者：
Bonecchi R;Graham GJ
通讯作者：
Graham GJ
影响因子：
20.3
作者：
Gomes, Ana L.;Carvalho, Tania;Dias, Sergio
通讯作者：
Dias, Sergio
DOI：
10.1165/rcmb.2011-0322oc
发表时间：
2012-08-01
影响因子：
6.4
作者：
Dai, Cuilian;Yao, Xianglan;Levine, Stewart J.
通讯作者：
Levine, Stewart J.
影响因子：
3.6
作者：
Broekhuizen, Lysette N.;van Wijk, Diederik F.;Stroes, Erik S. G.
通讯作者：
Stroes, Erik S. G.
影响因子：
20.3
作者：
Ghasemzadeh, Mehran;Kaplan, Zane S.;Jackson, Shaun P.
通讯作者：
Jackson, Shaun P.