Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration.
Paracrine effect of mesenchymal stem cells derived from human adipose tissue in bone regeneration.
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DOI：
10.1371/journal.pone.0107001
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Chaparro O
中科院分区：
文献类型：
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作者：
Linero I;Chaparro O
间充质干细胞（MSC）移植已被证明是细胞治疗和再生医学中一种很有前途的策略。虽然它们的作用机制尚不完全清楚，但有人认为它们的治疗活性可能是由旁分泌作用介导的。本研究的主要目的是通过放射学、形态学和组织学分析来评估来自人脂肪组织的间充质干细胞（Ad-MSC）及其条件培养基（CM）在体内模型（兔下颌骨）中修复外科骨损伤的能力。结果表明，Ad-MSC和CM均能诱导兔颌骨手术病变的骨再生，提示Ad-MSC主要通过释放旁分泌因子促进骨再生过程。MSC对骨再生的旁分泌作用的证据对再生医学有重大影响，使用其CM可以解决与细胞移植相关的一些问题和困难。特别是，CM易于储存和运输，并且在临床过程中更容易由医务人员处理。
Mesenchymal stem cell (MSC) transplantation has proved to be a promising strategy in cell therapy and regenerative medicine. Although their mechanism of action is not completely clear, it has been suggested that their therapeutic activity may be mediated by a paracrine effect. The main goal of this study was to evaluate by radiographic, morphometric and histological analysis the ability of mesenchymal stem cells derived from human adipose tissue (Ad-MSC) and their conditioned medium (CM), to repair surgical bone lesions using an in vivo model (rabbit mandibles). The results demonstrated that both, Ad-MSC and CM, induce bone regeneration in surgically created lesions in rabbit's jaws, suggesting that Ad-MSC improve the process of bone regeneration mainly by releasing paracrine factors. The evidence of the paracrine effect of MSC on bone regeneration has a major impact on regenerative medicine, and the use of their CM can address some issues and difficulties related to cell transplants. In particular, CM can be easily stored and transported, and is easier to handle by medical personnel during clinical procedures.
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