Systematic review of the evidence relating FEV1 decline to giving up smoking.
Systematic review of the evidence relating FEV1 decline to giving up smoking.
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DOI：
10.1186/1741-7015-8-84
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发表时间：
2010-12-14
期刊：
影响因子：
9.3
通讯作者：
Fry JS
中科院分区：
文献类型：
--
作者：
Lee PN;Fry JS
1秒用力呼气量(FEV1)下降率(“β”)是慢性阻塞性肺疾病风险的标志。戒烟后贝塔系数的降低是改用新型尼古丁递送产品所能实现的降幅上限。我们回顾了现有的证据，以估计这种减少，并量化吸烟与贝塔的关系。在健康个体或患有呼吸系统疾病的患者中，确定了分别针对戒烟者和其他吸烟组的研究，提供了至少两年随访期间的贝塔数据。审议了截至2010年6月的出版物。得出了四个主要吸烟组的独立贝塔估计值：从不吸烟者、戒烟者(基线前)、戒烟者(在随访期间)和持续吸烟者。未加权和逆方差加权回归分析按吸烟量比较吸烟组和持续吸烟者的Beta，并估计吸烟组之间的Beta或Beta差异是否因年龄、性别和其他因素而异。47项研究有相关数据，其中28项为两性研究，19项为男性研究。1970年之前开始了16项研究。平均随访11年。在对四个吸烟组的303个Beta进行加权分析的基础上，从不吸烟者的Beta值比持续吸烟者低10.8mL/年(95%可信区间为8.9~12.8)。戒烟者贝塔系数比继续吸烟者低12.4毫升/年(95%可信区间10.1~14.7)，戒烟者比戒烟者低8.5毫升/年(95%可信区间5.6~11.4)。这些测试版与从不吸烟者的测试版相似。在持续吸烟者中，每支香烟/天的β值增加了0.33毫升/年。在患有呼吸系统疾病或基线肺功能下降的患者中，持续吸烟者和戒烟者之间的β差异更大，但与年龄或性别没有明显关系。现有数据有许多局限性，但清楚地表明，持续吸烟者的贝塔系数与剂量有关，并且比从不吸烟者、戒烟者或戒烟者高出10毫升/年以上。患有呼吸系统疾病或肺功能减退的人下降幅度更大，这与一些吸烟者的FEV1下降速度更快是一致的。这些结果有助于设计研究，将继续吸食传统香烟和吸烟器的人与新产品进行比较。
The rate of forced expiratory volume in 1 second (FEV1) decline ("beta") is a marker of chronic obstructive pulmonary disease risk. The reduction in beta after quitting smoking is an upper limit for the reduction achievable from switching to novel nicotine delivery products. We review available evidence to estimate this reduction and quantify the relationship of smoking to beta. Studies were identified, in healthy individuals or patients with respiratory disease, that provided data on beta over at least 2 years of follow-up, separately for those who gave up smoking and other smoking groups. Publications to June 2010 were considered. Independent beta estimates were derived for four main smoking groups: never smokers, ex-smokers (before baseline), quitters (during follow-up) and continuing smokers. Unweighted and inverse variance-weighted regression analyses compared betas in the smoking groups, and in continuing smokers by amount smoked, and estimated whether beta or beta differences between smoking groups varied by age, sex and other factors. Forty-seven studies had relevant data, 28 for both sexes and 19 for males. Sixteen studies started before 1970. Mean follow-up was 11 years. On the basis of weighted analysis of 303 betas for the four smoking groups, never smokers had a beta 10.8 mL/yr (95% confidence interval (CI), 8.9 to 12.8) less than continuing smokers. Betas for ex-smokers were 12.4 mL/yr (95% CI, 10.1 to 14.7) less than for continuing smokers, and for quitters, 8.5 mL/yr (95% CI, 5.6 to 11.4) less. These betas were similar to that for never smokers. In continuing smokers, beta increased 0.33 mL/yr per cigarette/day. Beta differences between continuing smokers and those who gave up were greater in patients with respiratory disease or with reduced baseline lung function, but were not clearly related to age or sex. The available data have numerous limitations, but clearly show that continuing smokers have a beta that is dose-related and over 10 mL/yr greater than in never smokers, ex-smokers or quitters. The greater decline in those with respiratory disease or reduced lung function is consistent with some smokers having a more rapid rate of FEV1 decline. These results help in designing studies comparing continuing smokers of conventional cigarettes and switchers to novel products.
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影响因子：
10
作者：
Bednarek, M.;Gorecka, D.;Zielinski, J.
通讯作者：
Zielinski, J.
影响因子：
39.2
作者：
ASHLEY, F;KANNEL, WB;MASSON, R
通讯作者：
MASSON, R
影响因子：
5.7
作者：
Au, David H.;Bryson, Christopher L.;Bradley, Katharine A.
通讯作者：
Bradley, Katharine A.
DOI：
10.1097/00043798-199808000-00009
发表时间：
1998-08-01
期刊：
Journal of cardiovascular risk
影响因子：
--
作者：
Bartholomew, H C;Knuiman, M W
通讯作者：
Knuiman, M W
DOI：
10.1164/ajrccm/138.2.327
发表时间：
1988-08-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
BRANTLY, ML;PAUL, LD;CRYSTAL, RG
通讯作者：
CRYSTAL, RG