Objective sleep quality of healthy older men and women is differentially disrupted by nighttime periodic blood sampling via indwelling catheter.
Objective sleep quality of healthy older men and women is differentially disrupted by nighttime periodic blood sampling via indwelling catheter.
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夜间通过留置导管定期采血会不同程度地影响健康老年男性和女性的客观睡眠质量。
作者：
Vitiello,MV;Larsen,LH;Moe,KE;Borson,S;Schwartz,RS;Prinz,PN
要阐明睡眠与内分泌的关系，需要在睡眠记录过程中频繁采集血液样本。不幸的是，这种采样本身会影响睡眠，并间接影响荷尔蒙模式。我们研究了导尿术和频繁的夜间采血对健康老年男性和女性睡眠的影响。对113名健康老年人[69.1±0.6岁，平均年龄±标准差(SEM)]进行了研究，其中女性68人，男性45人。在适应之夜之后，在一个不受干扰的夜晚和一个通过静脉注射定期采血的夜晚记录睡眠。导管。导尿当晚，熄灯和亮灯的时间分别显著延迟和提前，导致卧床时间(TIB)显著缩短。总睡眠时间和睡眠效率显著减少，睡眠潜伏期、总觉醒时间和≥1分钟睡眠唤醒次数显著增加。TIB的快速眼动(REM)睡眠百分比明显降低。3/4期睡眠[慢波睡眠(SWS)]的TIB百分比显著降低，SWS期间的总增量能量也显著降低。除总睡眠时间和睡眠潜伏期外，所有睡眠-觉醒和增量变量在夜间之间显著相关。SWS和Delta能源变量的情况尤其如此。当按性别分开检查时，男性和女性都表现出明显的基于导管的睡眠障碍。然而，男性的SWS和Delta能量测量不受导尿术的影响。数据清楚地表明，健康的老年男性和女性的睡眠维持和睡眠结构都受到夜间采血程序的显著影响。在这里研究的各种措施中，SWS措施似乎是受影响最小的，特别是在男性身上。在任何利用老年受试者检查睡眠-内分泌关系的研究中，这些发现都需要被考虑在内。
Elucidation of sleep-endocrine relationships requires frequent blood sampling during sleep recording. Unfortunately, such sampling can itself affect sleep and indirectly, hormonal patterns. We examined the effect of catheterization and frequent nighttime blood sampling on the sleep of a large sample of healthy older men and women. A total of 113 healthy older [69.1 ± 0.6 years, mean ± standard error of the mean (SEM)] adults (68 women and 45 men) were studied. Following an adaptation night, sleep was recorded during an undisturbed night and a night of periodic blood sampling via i.v. catheter. Lights out and lights on were significantly delayed and advanced, respectively, on the catheterization night, resulting in a significantly shorter time in bed (TIB). Total sleep time and sleep efficiency were significantly reduced, and sleep latency, total wake time and the number of awakenings from sleep of ≥ 1 minute were significantly increased. Rapid eye movement (REM) sleep percentage of TIB was significantly reduced. Stages 3/4 sleep [slow wave sleep (SWS)] percentage of TIB was significantly reduced, as was total delta energy during SWS. With the exception of total sleep time and sleep latency, all sleep-wake and delta variables were significantly correlated between nights. This was particularly the case for SWS and the delta energy variables. When examined separately by gender, both men and women showed significant catheter-based sleep disturbance. However, SWS and delta energy measures in men were unaffected by catheterization. The data clearly demonstrate that both the sleep maintenance and sleep architecture of healthy older men and women are significantly impacted by nighttime blood sampling procedures. Of the various measures examined here, SWS measures appear to be the least disrupted, particularly in men. These findings need to be taken into account in any study examining sleep-endocrine relationships utilizing older subjects.
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1016/0013-4694(91)90141-p
发表时间：
1991
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
Larsen,LH;Prinz,PN
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影响因子：
10.6
作者：
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影响因子：
5.6
作者：
Prinz,PN;Larsen,LH;Moe,KE;Dulberg,EM;Vitiello,MV
通讯作者：
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