The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection.
The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection.
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DOI：
10.1016/j.yjmcc.2014.09.023
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发表时间：
2015-01
影响因子：
5
通讯作者：
Di Lisa, Fabio
中科院分区：
文献类型：
--
作者：
Bernardi, Paolo;Di Lisa, Fabio
线粒体通透性转换（PT）-内膜对溶质的通透性的突然增加-是心脏缺血-再灌注损伤的原因事件，并且是心脏保护的研究热点。PT是由于PT孔（PTP）的开放，PT孔是一种受多种病理生理效应物严格调节的高电导通道。最近的研究表明，PTP是由F-ATP合酶形成的，它将从一个能量保存装置转变为一个能量耗散装置。本文综述了目前关于如何实现这种转变的争论，以及PTP作为治疗干预目标的最新进展。本文是题为“线粒体：从基本线粒体生物学到心血管疾病”的特刊的一部分。线粒体通透性转换孔在心脏疾病中起着关键作用。对现有的渗透率转换孔隙模型进行了评述。F-ATP合成酶是最好的成孔分子候选者。亲环素D是一种重要的孔调节剂，但不是结构组分。亲环素抑制剂是有前途的，但混杂的药物。
The mitochondrial permeability transition (PT) – an abrupt increase permeability of the inner membrane to solutes – is a causative event in ischemia–reperfusion injury of the heart, and the focus of intense research in cardioprotection. The PT is due to opening of the PT pore (PTP), a high conductance channel that is critically regulated by a variety of pathophysiological effectors. Very recent work indicates that the PTP forms from the F-ATP synthase, which would switch from an energy-conserving to an energy-dissipating device. This review provides an update on the current debate on how this transition is achieved, and on the PTP as a target for therapeutic intervention. This article is part of a Special Issue entitled "Mitochondria: from basic mitochondrial biology to cardiovascular disease". The mitochondrial permeability transition pore plays a key role in heart disease. Existing models for the permeability transition pore are critically reviewed. F-ATP synthase is the best molecular candidate for pore formation. Cyclophilin D is an important pore regulator but not a structural component. Cyclophilin inhibitors are promising but promiscuous drugs.
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影响因子：
4.3
作者：
Bonora, Massimo;Bononi, Angela;Pinton, Paolo
通讯作者：
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影响因子：
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作者：
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DOI：
10.1111/j.1460-9568.2010.07576.x
发表时间：
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期刊：
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影响因子：
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通讯作者：
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影响因子：
2.7
作者：
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通讯作者：
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DOI：
10.1073/pnas.1401591111
发表时间：
2014-07-22
影响因子：
11.1
作者：
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通讯作者：
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