The use of preintervention and postintervention thallium imaging for assessing the early and late effects of experimental coronary arterial reperfusion in dogs.
The use of preintervention and postintervention thallium imaging for assessing the early and late effects of experimental coronary arterial reperfusion in dogs.
复制标题
使用干预前和干预后铊成像来评估狗实验性冠状动脉再灌注的早期和晚期影响。
作者：
R. Okada;G. Pohost
为了确定心肌灌注的Tl-201显像是否可以作为再灌注后心肌挽救的早期预测指标，24只成年犬在2小时后完全阻断冠状动脉左前降支并解除圈套。分别在诱捕器释放前15分钟、释放后5分钟和释放后1小时分别给予铊(1mCI)和微球。每次注射铊后，都会获得心脏的伽马相机图像。在第二次和第三次注射之前也采集了注射前的图像，并从注射后的图像中减去，以消除由于先前注射的残余活动而产生的计数。然后，箱子被关闭，狗被允许康复。48小时后重新打开胸腔，注射最后剂量的铊和微球，并对心脏进行成像。处死犬后，从心尖至心底切开左心室，用三苯基四氮唑(TTC)染色勾勒出梗死灶。然后将切片细分为每片约1g，然后进行充分计数，以确定局部心肌血流量的微球。对铊图像进行了定性和定量解释。15只心肌梗死犬，经TTC染色评估，在冠状动脉闭塞期间均有铊图像缺陷。再灌注后立即进行的铊扫描显示，9只狗的前壁铊活动增加，4只狗的活动正常，2只狗的活动减少。在15只狗中，有14只的相对铊活性与阻塞区/正常区血流比率相关。
To determine if thallium-201 imaging of myocardial perfusion can be used as an early predictor of myocardial salvage after reperfusion, 24 adult dogs were subjected to complete occlusion of the left anterior descending coronary artery with release of the snare 2 hr later. Separate doses of thallium (1 mCi) and microspheres were given 15 min before, 5 min after, and 1 hr after release of the snare. Gamma camera images of the heart were obtained after each injection of thallium. Preinjection images were also acquired before the second and third doses and were subtracted from the postinjection images to eliminate the counts due to residual activity from the prior injections. The chest was then closed and the dog allowed to recover. The chest was reopened 48 hr later, final doses of thallium and microspheres were administered, and the heart was imaged. After the dog was killed, the left ventricle was sliced from apex to base, and any infarct was outlined with triphenyltetrazolium (TTC) staining. The slices were then subdivided into pieces of approximately 1 g each and then well counted for microsphere determination of regional myocardial blood flows. Thallium images were interpreted qualitatively and quantitatively. Fifteen dogs with myocardial infarctions, as assessed by TTC staining, all had thallium image defects during coronary arterial occlusion. Thallium scans obtained immediately after reperfusion demonstrated increased anterior wall thallium activity in nine dogs, normal activity in four dogs, and decreased activity in two dogs. In 14 of the 15 dogs, relative thallium activity correlated with the occlusion/normal zone flow ratios.(ABSTRACT TRUNCATED AT 250 WORDS)
通过再灌注挽救心肌的长期异常。
DOI：
10.1152/ajpheart.1981.241.4.h591
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Kloner,RA;DeBoer,LW;Darsee,JR;Ingwall,JS;Hale,S;Tumas,J;Braunwald,E
通讯作者：
Braunwald,E
再灌注和非再灌注心肌梗死中铊 201 摄取的差异。
影响因子：
20.1
作者：
Melin,JA;Becker,LC;Bulkley,BH
通讯作者：
Bulkley,BH
急性心肌梗死进展中通过冠状动脉溶栓挽救心肌：使用冠状动脉注射铊 201 进行评估。
影响因子：
4.8
作者：
Maddahi,J;Ganz,W;Ninomiya,K;Hashida,J;Fishbein,MC;Mondkar,A;Buchbinder,N;Marcus,H;Geft,I;Shah,PK;Rozanski,A;Swan,HJ;Berman,DS
通讯作者：
Berman,DS