Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer.
Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer.
复制标题
DOI：
10.1038/bjc.2013.291
复制
发表时间：
2013-07-09
影响因子：
8.8
通讯作者：
McMillan DC
中科院分区：
文献类型：
--
作者：
Guthrie GJ;Roxburgh CS;Richards CH;Horgan PG;McMillan DC
以局部和全身炎症反应形式出现的癌症相关炎症似乎与肿瘤坏死有关，并对结直肠癌患者具有预后价值。然而，它们与循环生化介质的关系尚不清楚。本研究的目的是检查循环介质，特别是白细胞介素-6（IL-6）和肿瘤坏死，局部和全身炎症反应的结直肠癌切除术患者之间的相互关系。数据收集自118例接受结直肠癌切除术的患者的术前血液检查。分析循环IL-6、IL-10、血管内皮生长因子（VEGF）、分类白色细胞计数、C反应蛋白和白蛋白。常规病理学标本检查肿瘤特征，包括坏死和炎症细胞浸润的程度。采用体重指数（BMI）、全身脂肪、皮下脂肪、内脏脂肪和骨骼肌质量检查身体组成。循环中IL-6浓度与T分期（P<0.05）、肿瘤坏死（P<0.001）、IL-10（P<0.001）、VEGF（P<0.001）、改良格拉斯哥预后评分（mGPS; P<0.001）、白色细胞（P<0.01）和血小板（P<0.01）计数以及低骨骼肌指数（P<0.01）显著相关。当T分期正常化时，肿瘤坏死与IL-6相关，（P<0.001）、IL-10（P<0.01）、VEGF（P<0.001）、mGPS（P<0.001）、嗜中性粒细胞-淋巴细胞比率（NLR; P<0.05）、白色细胞（P<0.001）、中性粒细胞（P<0.05）、血小板计数（P<0.005）和骨骼肌指数（P<0.001）。本研究首次为以下假设提供了支持性证据：肿瘤坏死与T分期无关，与循环IL-6浓度升高相关，从而调节局部和全身炎症反应，包括血管生成，进而可能促进肿瘤进展和转移。
Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have prognostic value in patients with colorectal cancer. However, their relationship with circulating biochemical mediators is unclear. The aim of the present study was to examine the interrelationships between circulating mediators, in particular interleukin-6 (IL-6) and tumour necrosis, and local and systemic inflammatory responses in patients undergoing resection for colorectal cancer. Data were collected from preoperative blood tests for 118 patients who underwent resection for colorectal cancer. Analysis of circulating IL-6, IL-10, vascular endothelial growth factor (VEGF), differential white cell count, C-reactive protein, and albumin were carried out. Routine pathology specimens were examined for tumour characteristics including necrosis and the extent of the inflammatory cell infiltrate. Body composition was examined using body mass index (BMI), total body fat, subcutaneous body fat, visceral fat, and skeletal muscle mass. Circulating IL-6 concentrations were significantly associated with increased T stage (P<0.05), tumour necrosis (P<0.001), IL-10 (P<0.001), VEGF (P<0.001), modified Glasgow Prognostic Score (mGPS; P<0.001), white cell (P<0.01) and platelet (P<0.01) counts, and low skeletal muscle index (P<0.01). When normalised for T stage, tumour necrosis was associated with IL-6 (P<0.001), IL-10 (P<0.01), VEGF (P<0.001), mGPS (P<0.001), neutrophil–lymphocyte ratio (NLR; P<0.05), white cell (P<0.001), neutrophil (P<0.05), and platelet counts (P<0.005), and skeletal muscle index (P<0.001). The present study provides, for the first time, supportive evidence for the hypothesis that tumour necrosis, independent of T stage, is associated with elevated circulating IL-6 concentrations, thereby modulating both local and systemic inflammatory responses including angiogenesis that, in turn, may promote tumour progression and metastases.
登录
查看更多内容
影响因子：
3.9
作者：
Piancatelli, D;Romano, P;Casciani, CU
通讯作者：
Casciani, CU
影响因子：
11.2
作者：
Movahedi, Kiavash;Laoui, Damya;Van Ginderachter, Jo A.
通讯作者：
Van Ginderachter, Jo A.
影响因子：
3.3
作者：
Pollheimer, Marion J.;Kornprat, Peter;Langner, Cord
通讯作者：
Langner, Cord
影响因子：
11.5
作者：
Forssell, Johan;Oeberg, Ake;Palmqvist, Richard
通讯作者：
Palmqvist, Richard
影响因子：
--
作者：
Kinouchi, Makoto;Miura, Koh;Unno, Michiaki
通讯作者：
Unno, Michiaki