Enterococcal Endocarditis: Hiding in Plain Sight.
Enterococcal Endocarditis: Hiding in Plain Sight.
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肠球菌性心内膜炎：隐藏在明显的视线中。
DOI：
10.3389/fcimb.2021.722482
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发表时间：
2021
影响因子：
5.7
通讯作者：
Dunny GM
中科院分区：
文献类型：
--
作者：
Barnes AMT;Frank KL;Dunny GM
粪肠球菌是一种重要的机会致病菌，临床意义日益增加。大量实验证据表明，早期生物膜形成在这些感染中起关键作用，以及在大多数陆生动物中作为微生物组的寄生成员在胃肠道中的定殖和持久性中起关键作用。实验性心内膜炎的动物模型通常涉及在感染前通过心导管插入术诱导机械瓣膜损伤，并且长期以来一直认为细菌附着于心内膜内皮导致的心内膜炎赘生物形成需要一些预先存在的组织损伤。在这里，我们回顾了历史和当代的动物模型研究，证明了E。粪肠球菌直接附着并在未受损的血管内内皮表面上形成包裹在细菌来源的细胞外基质内的稳定的微菌落生物膜。我们还讨论了当这些生物膜在其他宿主组织上形成时的形态学相似性，包括当E。粪肠球菌作为正常脊椎动物微生物组的肠道成员定植在胃肠道上皮上-隐藏在显而易见的地方，在那里它可以通过易位作为全身感染的来源。我们认为，这些表型可能使微生物持续作为一个未被发现的感染在无症状的个人，从而提供了一个感染水库，为后来的临床心内膜炎。
Enterococcus faecalis is a major opportunistic bacterial pathogen of increasing clinical relevance. A substantial body of experimental evidence suggests that early biofilm formation plays a critical role in these infections, as well as in colonization and persistence in the GI tract as a commensal member of the microbiome in most terrestrial animals. Animal models of experimental endocarditis generally involve inducing mechanical valve damage by cardiac catheterization prior to infection, and it has long been presumed that endocarditis vegetation formation resulting from bacterial attachment to the endocardial endothelium requires some pre-existing tissue damage. Here we review both historical and contemporary animal model studies demonstrating the robust ability of E. faecalis to directly attach and form stable microcolony biofilms encased within a bacterially-derived extracellular matrix on the undamaged endovascular endothelial surface. We also discuss the morphological similarities when these biofilms form on other host tissues, including when E. faecalis colonizes the GI epithelium as a commensal member of the normal vertebrate microbiome - hiding in plain sight where it can serve as a source for systemic infection via translocation. We propose that these phenotypes may allow the organism to persist as an undetected infection in asymptomatic individuals and thus provide an infectious reservoir for later clinical endocarditis.
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影响因子：
12.3
作者：
Bourgogne, Agathe;Garsin, Danielle A.;Qin, Xiang;Singh, Kavindra V.;Sillanpaa, Jouko;Yerrapragada, Shailaja;Ding, Yan;Dugan-Rocha, Shannon;Buhay, Christian;Shen, Hua;Chen, Guan;Williams, Gabrielle;Muzny, Donna;Maadani, Arash;Fox, Kristina A.;Gioia, Jason;Chen, Lei;Shang, Yue;Arias, Cesar A.;Nallapareddy, Sreedhar R.;Zhao, Meng;Prakash, Vittal P.;Chowdhury, Shahreen;Jiang, Huaiyang;Gibbs, Richard A.;Murray, Barbara E.;Highlander, Sarah K.;Weinstock, George M.
通讯作者：
Weinstock, George M.
影响因子：
6.4
作者：
Brown, Armand O.;Singh, Kavindra, V;Garsin, Danielle A.
通讯作者：
Garsin, Danielle A.
影响因子：
3.1
作者：
Frank, Kristi L.;Guiton, Pascale S.;Dunny, Gary M.
通讯作者：
Dunny, Gary M.
DOI：
10.1007/s10096-020-04117-x
发表时间：
2021-01-06
影响因子：
4.5
作者：
Escola-Verge, Laura;Fernandez-Hidalgo, Nuria;Almirante, Benito
通讯作者：
Almirante, Benito
影响因子：
6.7
作者：
Brown AO;Garsin DA
通讯作者：
Garsin DA