Early posttransplant changes in circulating endothelial microparticles in patients with kidney transplantation.
Early posttransplant changes in circulating endothelial microparticles in patients with kidney transplantation.
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DOI：
10.1016/j.trim.2014.06.006
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发表时间：
2014-08
影响因子：
1.5
通讯作者：
Brodsky SV
中科院分区：
文献类型：
--
作者：
Qamri Z;Pelletier R;Foster J;Kumar S;Momani H;Ware K;Von Visger J;Satoskar A;Nadasdy T;Brodsky SV
内皮微粒（Endothelial Microparticles，EMP）是内皮细胞因损伤、活化或凋亡而脱落的膜泡。肾移植（KTx）是终末期肾病（ESKD）患者的首选治疗方法。本研究的目的是分析KTx后患者EMP和血清肌酐（SCr）的变化。在KTx之前（KTx之前）和之后两个月定期收集患者的血液。EMP被鉴定为CD 31 +/CD 42 b −微粒，并通过荧光激活细胞扫描进行定量。这项研究包括213名KTx，14名肾脏/胰腺（KPTx）受体和60名捐赠前的健康供体。根据ESKD的病因将受者分为5组。在前KPTx或KTx受体血清和健康供体血清中未观察到循环EMP的量的差异。继发于糖尿病、梗阻性/遗传性肾病和自身免疫性疾病的ESKD患者在KTx后60天循环EMP和SCr均降低。在选择性ESKD患者中，肾KTx后观察到循环EMP和SCr均降低。
Endothelial microparticles (EMP) are membrane vesicles shed from endothelial cell in response to injury, activation or apoptosis. Kidney transplantation (KTx) is the treatment of choice for patients with end stage kidney disease (ESKD). The aim of this study was to analyze changes in EMP and serum creatinine (SCr) in patients following KTx. Blood was periodically collected from patients before (pre-KTx) and after KTx for two months. EMP were identified as CD31+/CD42b− microparticles and quantified by fluorescence-activated cell scanning. This study included 213 KTx, 14 kidney/pancreas (KPTx) recipients and 60 healthy donors prior to donation. The recipients were divided into 5 groups based on the cause of ESKD. No differences in the quantity of circulating EMP were seen in the pre-KPTx or KTx recipient sera and healthy donor sera. Patients with ESKD secondary to diabetes mellitus, obstructive/inherited kidney disease and autoimmune disease had a decrease in both circulating EMP and SCr by day 60 after KTx. Reduction in both circulating EMP and SCr was seen after kidney KTx in patients with selective ESKD.
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影响因子：
20.1
作者：
Brodsky, SV;Gealekman, O;Goligorsky, MS
通讯作者：
Goligorsky, MS
影响因子：
37.8
作者：
Mallat, Z;Hugel, B;Tedgui, A
通讯作者：
Tedgui, A
影响因子：
19.6
作者：
Daniel, L;Fakhouri, F;Halbwachs-Mecarelli, L
通讯作者：
Halbwachs-Mecarelli, L
影响因子：
37.8
作者：
Brodsky, SV;Malinowski, K;Goligorsky, MS
通讯作者：
Goligorsky, MS
影响因子：
8.8
作者：
Al-Massarani, G.;Vacher-Coponat, H.;Camoin-Jau, L.
通讯作者：
Camoin-Jau, L.