Increased oxidative stress in patients with hydatidiform mole.
Increased oxidative stress in patients with hydatidiform mole.
复制标题
葡萄胎患者氧化应激增加。
DOI：
10.4414/smw.2003.10397
复制
发表时间：
2003
影响因子：
2.9
通讯作者：
O. Erel
中科院分区：
文献类型：
--
作者：
M. Harma;M. Harma;O. Erel
目的
本研究的目的是确定完全性葡萄胎（CHM）患者血浆的氧化状态和抗氧化状态，并将这些值与正常妊娠进行比较。
方法
38例CHM患者和31例健康孕妇入组研究。测定血浆总抗氧化潜能（TAOP），测定血浆总过氧化物水平，以确定血浆的抗氧化状态。TAOP与总过氧化物的比率被接受为氧化应激的指标。
结果
葡萄胎患者血浆TAOP显著低于健康孕妇[平均（SD）值分别为511.9（105.8）和571.7（109.4）微摩尔Trolox当量/ L（p <0.05）]。相反，患者血浆中平均（SD）总过氧化物水平[21.8（6.4）μ mol H2 O2/L]显著高于健康孕妇[15.6（6.4）μ mol H2 O2/L（p <0.001）]。CHM患者的平均氧化应激指数水平显著高于健康孕妇[分别为4.43（1.70）和2.92（1.50）（p <0.001）]。
结论
CHM患者暴露于氧化应激，这可能在疾病的发病机制中起作用。在治疗中可以考虑补充抗氧化维生素，如C和E。
OBJECTIVE
The aim of this study was to determine the oxidative status and antioxidative status of plasma of patients with complete hydatidiform mole (CHM) and to compare these values with normal pregnancy.
METHOD
Thirty-eight patients with CHM and 31 healthy pregnant women were enrolled in the study. To determine the antioxidative status of plasma, total antioxidant potential (TAOP) was calculated, and to determine the oxidative status of plasma total peroxide levels were measured. The ratio of TAOP to total peroxide was accepted as an indicator of oxidative stress.
RESULTS
TAOP of plasma was significantly lower in patients with hydatidiform mole than in healthy pregnant women [mean (SD) values were 511.9 (105.8) and 571.7 (109.4) micromol Trolox equiv./L respectively (p <0.05)]. In contrast, mean (SD) total peroxide level of plasma was significantly higher in the patients [21.8 (6.4) micromol H2O2/L] than in healthy pregnant women [15.6 (6.4) micromol H2O2/L (p <0.001)]. The mean oxidative stress index level was significantly higher in patients with CHM than in healthy pregnant women [4.43 (1.70) versus 2.92 (1.50) respectively (p <0.001)].
CONCLUSION
Patients with CHM are exposed to oxidative stress, which may have a role in the pathogenesis of the disease. Supplementation with antioxidative vitamins such as C and E could be considered in treatment.
影响因子：
6
作者：
Many, A;Hubel, CA;Zhou, Y
通讯作者：
Zhou, Y