Objective and subjective childhood socioeconomic disadvantage and incident depression in adulthood: a longitudinal analysis in the Sister Study.
Objective and subjective childhood socioeconomic disadvantage and incident depression in adulthood: a longitudinal analysis in the Sister Study.
复制标题
DOI：
10.1007/s00127-020-02013-5
复制
发表时间：
2021-07
影响因子：
4.4
通讯作者：
Sandler DP
中科院分区：
文献类型：
--
作者：
Simanek AM;Meier HCS;D'Aloisio AA;Sandler DP
对客观与主观童年社会经济劣势（SD）在女性成年期抑郁症发病中的作用的理解是有限的，独立于以后的生活SD，并跨越出生队列。我们在姐妹研究中对47,055名女性进行了客观（即家庭教育水平）和主观（即家庭收入等级和食物不足报告）儿童期SD与30岁后临床抑郁症诊断之间的关联。我们使用Cox比例风险模型调整了女性的种族/民族、童年家庭组成、母亲出生时的年龄、成年后的受教育程度和出生日历年。按10岁出生组重复分层分析。在平均24.0（±9.9）年的随访中，共有8036名（17.1%）女性被诊断为抑郁症。那些在童年时期报告贫穷（相对于富裕）或没有足够食物的人的抑郁症诊断率分别高出1.28（95%可信区间（CI） 1.13, 1.44）和1.30 （95% CI 1.21, 1.41）倍，在出生年份组中观察到一致的关联。在基线（即30岁）观察到低家庭教育水平与事件抑郁症之间呈负相关，随着时间的推移在总样本中呈正相关，但在按10年出生组分层的分析中，仅在1935-1954年出生的女性中呈正相关。我们的研究结果表明，童年时期的主观抑郁障碍在很大程度上是女性成年后抑郁发病的一致预测因素，而童年时期家庭教育水平的影响可能因出生在不同出生队列的女性而异，对一些人来说，在整个生命过程中都会有所不同。
Understanding of the role of objective versus subjective childhood socioeconomic disadvantage (SD) in depression onset in adulthood among women, independent of later life SD, and across birth cohorts, is limited. We examined the association between objective (i.e., household education level) and subjective (i.e., rank of family income and report of not enough food to eat) SD during childhood and diagnosis of clinical depression after age 30 among 47,055 women in the Sister Study. We used Cox proportional hazard models adjusting for women’s race/ethnicity, childhood household composition, mother’s age at her birth, adulthood educational attainment, and calendar year of birth. Analyses were repeated stratified by 10-year birth group. A total of 8,036 (17.1%) women were diagnosed with depression over a mean follow-up of 24.0 (± 9.9) years. Those reporting being poor (versus well-off) or not having enough food to eat in childhood had a 1.28 (95% confidence interval (CI) 1.13, 1.44) and 1.30 (95% CI 1.21, 1.41) times higher rate of depression diagnosis, respectively, with consistent associations observed across birth year groups. An inverse association between low household education level and incident depression was observed at baseline (i.e., age 30) becoming positive over time in the total sample but only among women born between 1935–1954 in analyses stratified by 10-year birth group. Our findings suggest that subjective SD in childhood is a largely consistent predictor of depression onset among women in adulthood whereas the effects of household education level in childhood may vary across women born into different birth cohorts, and for some, across the lifecourse.
登录
查看更多内容
影响因子：
7.7
作者：
Laaksonen, Elina;Martikainen, Pekka;Marmot, Michael
通讯作者：
Marmot, Michael
DOI：
10.1093/geronb/gby028
发表时间：
2019-01-01
影响因子：
6.2
作者：
Angelini, Viola;Howdon, Daniel D. H.;Mierau, Jochen O.
通讯作者：
Mierau, Jochen O.
影响因子：
5.4
作者：
Darin-Mattsson, Alexander;Andel, Ross;Kareholt, Ingemar
通讯作者：
Kareholt, Ingemar
影响因子：
6.9
作者：
Gale, C. R.;Sayer, A. Aihie;Deary, I. J.
通讯作者：
Deary, I. J.
影响因子：
11.3
作者：
Lindstrom, Martin;Fridh, Maria;Rosvall, Maria
通讯作者：
Rosvall, Maria