Prefrontal Cortical Opioids and Dysregulated Motivation: A Network Hypothesis.
Prefrontal Cortical Opioids and Dysregulated Motivation: A Network Hypothesis.
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DOI：
10.1016/j.tins.2016.03.004
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发表时间：
2016-06
影响因子：
15.9
通讯作者：
Baldo BA
中科院分区：
文献类型：
--
作者：
Baldo BA
对食欲动机行为的抑制控制的丧失发生在多种精神疾病中，包括药物滥用、行为成瘾和具有狂欢特征的饮食障碍。在这篇观点文章中，将讨论μ-阿片肽在前额叶皮层（PFC）中可能导致抑制性控制缺陷的新作用。已有证据表明，PFC μ-阿片受体（μ-OR）内过度信号传导改变了PFC对兴奋性驱动的反应，导致多个PFC输出通路的超常和不连贯的募集。受影响的通路包括功能上相反的PFC→下丘脑“食欲驱动”和PFC→纹状体“食欲限制”投射。这种网络扰动导致了混乱的、冲动的食欲反应。将讨论来自人类成像和动物研究的支持这一假设的证据，并将探索靶向μ-OR和特定PFC皮质下靶点的组合药物治疗。
Loss of inhibitory control over appetitively motivated behavior occurs in multiple psychiatric disorders, including drug abuse, behavioral addictions, and eating disorders with binge features. In this opinion article, novel actions of μ-opioid peptides in the prefrontal cortex (PFC) that could contribute to inhibitory control deficits will be discussed. Evidence has accrued to suggest that excessive intra-PFC μ-opioid receptor (μ-OR) signaling alters the PFC response to excitatory drive, resulting in supernormal and incoherent recruitment of multiple PFC output pathways. Affected pathways include functionally opposed PFC→hypothalamus ‘appetitive driver’ and PFC→striatum ‘appetitive limiter’ projections. This network perturbation engenders disorganized, impulsive appetitive responses. Evidence supporting this hypothesis from human imaging and animal studies will be discussed, and combinatorial drug treatments targeting μ-ORs and specific PFC subcortical targets will be explored.
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影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
影响因子：
4.3
作者：
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通讯作者：
Rorick-Kehn LM
DOI：
10.1111/j.1530-0277.2011.01535.x
发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
de Lecea, Luis
DOI：
10.1007/s40519-014-0173-9
发表时间：
2015-03
期刊：
Eating and weight disorders : EWD
影响因子：
--
作者：
Ágh T;Kovács G;Pawaskar M;Supina D;Inotai A;Vokó Z
通讯作者：
Vokó Z