SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma.
SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma.
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DOI：
10.1007/s00428-014-1667-6
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发表时间：
2014-12
期刊：
影响因子：
3.5
通讯作者：
Eberhard, Jakob
中科院分区：
文献类型：
--
作者：
Hedner, Charlotta;Gaber, Alexander;Korkocic, Dejan;Nodin, Bjorn;Uhlen, Mathias;Kuteeva, Eugenia;Johannesson, Henrik;Jirstrom, Karin;Eberhard, Jakob
胃癌是世界范围内第二大常见的癌症相关死亡原因，食管腺癌的发病率正在上升。虽然在治疗策略方面取得了一些进展，但上消化道腺癌患者的总体生存率仍然很低。富含AT的序列结合蛋白1（SATB 1）是一种全球性的基因组组织者，已被证明在几种不同类型的癌症（包括胃癌）中促进侵袭性肿瘤行为。然而，SATB 1表达在食管癌中的预后价值尚未被描述。在这项研究中，SATB 1的表达进行了检查，从175例食管腺癌，贲门癌，或胃癌患者的组织样本，并含有正常组织，肠上皮化生，原发性肿瘤，和转移的组织微阵列的免疫组织化学。使用经过充分验证的抗体。我们发现SATB 1是一个独立的预后因素，在根治性切除肿瘤的患者，与较短的总生存期以及较短的无复发生存期。SATB 1的表达在伴有肠上皮化生的原发性肿瘤中也明显低于不伴有肠上皮化生的原发性肿瘤。这一观察结果具有潜在的生物学意义，因为已经提出肠化生相关肿瘤构成侵袭性较低的表型。本文的在线版本（doi：10.1007/s 00428 -014-1667-6）包含补充材料，可供授权用户使用。
Gastric cancer is the second most common cause of cancer-related death worldwide, and the incidence of esophageal adenocarcinoma is rising. While some progress has been made in treatment strategies, overall survival remains very poor for patients with adenocarcinoma in the upper gastrointestinal tract. Special AT-rich sequence binding protein 1 (SATB1) is a global genome organizer that has been demonstrated to promote aggressive tumor behavior in several different types of cancer, including gastric cancer. The prognostic value of SATB1 expression in esophageal cancer has, however, not yet been described. In this study, expression of SATB1 was examined by immunohistochemistry on tissue microarrays prepared from tissue samples from 175 patients with adenocarcinoma of the esophagus, cardia, or stomach and containing normal tissue, intestinal metaplasia, primary tumors, and metastases. A well-validated antibody was used. We found SATB1 to be an independent prognostic factor in patients with a radically resected tumor, correlating with shorter overall survival as well as with shorter recurrence-free survival. SATB1 expression was also found to be significantly lower in primary tumors associated with intestinal metaplasia than those without intestinal metaplasia. This observation is of potential biological interest as it has been proposed that intestinal metaplasia-associated tumors constitute a less aggressive phenotype. The online version of this article (doi:10.1007/s00428-014-1667-6) contains supplementary material, which is available to authorized users.
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