Saturable absorption of glycerol in the rat intestine.
Saturable absorption of glycerol in the rat intestine.
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甘油在大鼠肠道中的饱和吸收。
DOI：
10.1248/bpb.26.1633
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发表时间：
2003
影响因子：
2
通讯作者：
J. Watanabe
中科院分区：
文献类型：
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作者：
H. Yuasa;Kaori Hamamoto;Shin;Takeshi Marutani;Akihumi Nakajima;Toyonori Kato;Y. Hayashi;Katsuhisa Inoue;J. Watanabe
如果通常认为这类溶质的主要运输机制是局限于细胞旁的被动扩散，那么甘油这种小的亲水溶质穿过肠膜的渗透性就会很低。然而，在目前使用大鼠小肠原位闭合环的研究中，我们发现甘油的吸收比尿素的吸收快，尿素是一种广泛认为只通过细胞旁途径渗透的探针溶质。这一发现与细胞旁渗透假说不一致，该假说预测甘油的吸收，在分子大小上比尿素大，不可能比尿素快。我们还发现甘油的吸收是饱和的。这些发现表明，载体介导的转运参与了肠道甘油吸收。甘油在结肠中的吸收也是饱和的，这表明参与了载体介导的运输，尽管它比在小肠中的要慢得多。载体介导的甘油运输可能在吸收从膳食甘油三酯中释放的甘油中起重要作用。进一步研究载体介导的甘油转运系统（或多个系统）参与药物吸收的可能性，以及它可能用于口服药物递送的可能性，将是一件有趣的事情。
The permeability of glycerol, a small hydrophilic solute, across the intestinal membrane would be low, if passive diffusion restricted to the paracellular route is the principal transport mechanism as generally assumed for this class of solutes. However, in the present study using a closed loop of rat small intestine in situ, we found that the absorption of glycerol was faster than that of urea, a probe solute widely assumed to permeate exclusively via the paracellular route. This finding is inconsistent with the paracellular permeation hypothesis, which predicts that the absorption of glycerol, which is larger than urea in terms of molecular size, could not be faster than that of urea. We also found that glycerol absorption was saturable. These findings suggest the involvement of carrier-mediated transport in intestinal glycerol absorption. Glycerol absorption in the colon was also saturable, suggesting the involvement of carrier-mediated transport, although it was much slower than that in the small intestine. Carrier-mediated glycerol transport might play an important role in absorbing glycerol liberated from dietary triglyceride. It would be interesting to further examine the possibility that a carrier-mediated glycerol transport system (or systems) might be involved in drug absorption and also that it might be utilized for oral drug delivery.
影响因子：
3.5
作者：
Okada, S;Misaka, T;Abe, K
通讯作者：
Abe, K
富田干雄：药物研究。
DOI：
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