LuxR-type quorum-sensing regulators that are detached from common scents.
LuxR-type quorum-sensing regulators that are detached from common scents.
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DOI：
10.1111/j.1365-2958.2010.07279.x
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发表时间：
2010-09
影响因子：
3.6
通讯作者：
Winans SC
中科院分区：
文献类型：
--
作者：
Tsai CS;Winans SC
LuxR型蛋白调节转录的能力由细菌信息素N-酰基高丝氨酸内酯（AHLs）控制。大多数LuxR家族蛋白质需要其同源AHLs来进行活性，并且其中至少一些需要AHLs来进行折叠和蛋白酶抗性。然而，这个家族的一些成员能够折叠，二聚化，结合DNA，并在没有AHL的情况下调节转录;此外，这些蛋白质被其同源AHL拮抗。这些蛋白质和它们的DNA结合位点之间的复合物在体外被AHLs破坏。所有这些蛋白质在较大的LuxR家族中都是相当密切相关的，这表明它们有一个相对较近的共同祖先。编码这些受体的基因的3′端总是与同源阿勒合酶基因的3′端重叠，表明在mRNA合成、稳定性或翻译水平上存在额外的拮抗作用。
The ability of LuxR-type proteins to regulate transcription is controlled by bacterial pheromones, N-acylhomoserine lactones (AHLs). Most LuxR-family proteins require their cognate AHLs for activity, and at least some of them require AHLs for folding and protease-resistance. However, a few members of this family are able to fold, dimerize, bind DNA, and regulate transcription in the absence of AHLs; moreover, these proteins are antagonized by their cognate AHLs. Complexes between some of these proteins and their DNA binding sites are disrupted by AHLs in vitro. All such proteins are fairly closely related within the larger LuxR family, indicating that they share a relatively recent common ancestor. The 3′ ends of the genes encoding these receptors invariably overlap with the 3′ ends of the cognate AHL synthase genes, suggesting additional antagonism at the level of mRNA synthesis, stability, or translation.
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影响因子：
3.2
作者：
BRINT, JM;OHMAN, DE
通讯作者：
OHMAN, DE
DOI：
10.1073/pnas.88.24.11115
发表时间：
1991-12-01
影响因子：
11.1
作者：
CHOI, SH;GREENBERG, EP
通讯作者：
GREENBERG, EP
影响因子：
3.6
作者：
Costa, Esther D.;Cho, Hongbaek;Winans, Stephen C.
通讯作者：
Winans, Stephen C.
影响因子：
14.9
作者：
ENGEBRECHT, J;SILVERMAN, M
通讯作者：
SILVERMAN, M
影响因子：
4.8
作者：
Bottomley, Matthew J.;Muraglia, Ester;Carfi, Andrea
通讯作者：
Carfi, Andrea