Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.
Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.
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DOI：
10.1016/j.ebiom.2017.06.015
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发表时间：
2017-07
期刊：
影响因子：
11.1
通讯作者：
Anderson RM
中科院分区：
文献类型：
--
作者：
Balasubramanian P;Howell PR;Anderson RM
与传统的医学研究相比，衰老作为一项研究是相当新的。越来越多的研究人员致力于了解组织生物学、生理学和全身稳态的变化如何随着年龄的增长而共同导致疾病的脆弱性增加。老龄化研究作为一门学科必然是广泛的；部分原因是衰老本身是多方面的，部分原因是采用不同的模型系统来定义潜在的生物学。在这篇综述中，我们概述了衰老研究的各个方面，这些方面可能会揭示导致与年龄相关的疾病脆弱性的关键事件。我们专注于人类衰老的研究，并讨论热量限制研究的价值，热量限制是一种已被证明能有效延缓衰老的干预措施。我们建议此类研究将提供导致人类衰老脆弱性的目标因素和过程，这一进步可能会改变临床护理。热量限制可以延缓衰老，是了解与年龄相关的疾病脆弱性的生物学的有力工具。 CR 诱导的机制有望开发针对年龄相关疾病的干预措施。非人类灵长类动物是从生物学洞察到人类临床应用过渡的绝佳模型。
Aging as a research pursuit is fairly new compared with traditional lines of medical research. A growing field of investigators is focused on understanding how changes in tissue biology, physiology, and systemic homeostasis, conspire to create increased vulnerability to disease as a function of age. Aging research as a discipline is necessarily broad; in part because aging itself is multi-faceted and in part because different model systems are employed to define the underlying biology. In this review we outline aspects of aging research that are likely to uncover the pivotal events leading to age-related disease vulnerability. We focus on studies of human aging and discuss the value of research on caloric restriction, an intervention with proven efficacy in delaying aging. We propose that studies such as these will deliver target factors and processes that create vulnerability in human aging, an advance that would potentially be transformative in clinical care. Caloric restriction delays aging and is a powerful tool for understanding the biology of age-related disease vulnerability. Mechanisms induced by CR hold promise for the development of interventions for age-associated disease. Nonhuman primates are an excellent model for transition from biological insight to human clinical application.
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DOI：
10.1152/physiol.00010.2011
发表时间：
2011-08
期刊：
Physiology (Bethesda, Md.)
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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发表时间：
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期刊：
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影响因子：
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DOI：
10.1093/gerona/53a.6.b443
发表时间：
1998-11-01
影响因子：
5.1
作者：
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通讯作者：
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