Comparison of subjective and objective hot flash measures over time among breast cancer survivors initiating aromatase inhibitor therapy.
Comparison of subjective and objective hot flash measures over time among breast cancer survivors initiating aromatase inhibitor therapy.
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DOI：
10.1097/gme.0b013e3181a5d0d6
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Carpenter JS
中科院分区：
文献类型：
--
作者：
Otte JL;Flockhart D;Hayes D;Storniolo AM;Stearns V;Schneider B;Henry NL;Azzouz F;Nguyen A;Lemler S;Hayden J;Jeter S;Wright L;Carpenter JS
潮热是生理状况和药物作用的有价值的指标;然而，主观和客观的测量并不总是一致的。没有研究检查主观和客观的潮热妇女处方芳香酶抑制剂。该研究（1）比较了主观和客观潮热指标，（2）检查了主观和客观潮热随时间的变化，（3）评估了芳香酶抑制剂治疗女性潮热变化的预测因素。受试者（n=135）参加了一项比较阿伐美坦和来曲唑治疗乳腺癌的随机临床试验。在开始给药前以及给药后1、3和6个月对潮热进行评估。受试者在每个时间点佩戴胸骨皮肤电导监测仪≥ 24小时。每次感觉到潮热，女性都按下一个事件按钮，并在纸质日记中对强度和烦恼进行评级。受试者的平均年龄为60岁，主要为白人（92%）。在各个时间点，监测器潮热（1）比日记和/或事件按钮闪光更频繁（p<0.05），（2）与主观测量中度相关（0.35 < r <0.56）。芳香化酶抑制剂治疗后，监测热潮红未随时间发生显著变化，而日记和事件按钮频率均发生显著变化，但模式不同（51%为非线性）。在不同的测量或时间点，未发现一致的潮热预测因子。结果表明潮热的主观和客观措施之间的差异。尽管有统计学意义，但在开始芳香化酶抑制剂治疗后，潮热几乎没有临床意义的变化。
Hot flashes are valuable indicators of physiologic condition and drug effect; however, subjective and objective measures do not always agree. No study has examined both subjective and objective hot flashes in women prescribed aromatase inhibitors. The study (1) compared subjective and objective hot flash measures, (2) examined changes in subjective and objective hot flashes over time, and (3) evaluated predictors of change in hot flashes in aromatase inhibitor-treated women. Subjects (n=135) were enrolled in a randomized clinical trial comparing exemestane and letrozole for the treatment of breast cancer. Hot flashes were assessed prior to starting drug and 1, 3, and 6 months later. Subjects wore a sternal skin conductance monitor for ≥ 24 hours at each time point. With each perceived hot flash, women pressed an event button and rated intensity and bother in a paper diary. Subjects were a mean age of 60 years and mainly Caucasian (92%). Across time points, monitor hot flashes were (1) significantly more frequent than diary and/or event button flashes (p<.05) and (2) moderately correlated with subjective measures (.35< r <.56). Monitor hot flashes did not significantly change over time with aromatase inhibitor therapy, whereas both diary and event button frequency significantly varied but in dissimilar patterns (51% non-linear). No consistent predictors of hot flashes across measures or time points were identified. Findings indicated dissimilarities between subjective and objective measures of hot flashes. Despite statistical significance, there was little clinically meaningful change in hot flashes after initiating aromatase inhibitor therapy.
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影响因子：
--
作者：
Huang, Alison J.;Grady, Deborah;Sawaya, George F.
通讯作者：
Sawaya, George F.
影响因子：
7.2
作者：
Carpenter, JS;Monahan, PO
通讯作者：
Monahan, PO
DOI：
10.1097/00042192-199906030-00006
发表时间：
1999-09-01
影响因子：
2.7
作者：
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通讯作者：
Munn, R
影响因子：
45.3
作者：
Fallowfield, L;Cella, D;Howell, A
通讯作者：
Howell, A
影响因子：
9.8
作者：
Aldrighi, JM;Quail, DC;Nickelsen, T
通讯作者：
Nickelsen, T