Roles of mast cells in the pathogenesis of inflammatory myopathy.
Roles of mast cells in the pathogenesis of inflammatory myopathy.
复制标题
DOI：
10.1186/ar4512
复制
发表时间：
2014-03-17
影响因子：
4.9
通讯作者：
Nakajima H
中科院分区：
文献类型：
--
作者：
Yokota M;Suzuki K;Tokoyoda K;Meguro K;Hosokawa J;Tanaka S;Ikeda K;Mikata T;Nakayama T;Kohsaka H;Nakajima H
除了肥大细胞在过敏性疾病中的关键作用外，最近的数据表明肥大细胞在各种自身免疫反应中起关键作用。然而，尽管它们在骨骼肌中的分布，但它们在自身免疫性骨骼肌疾病发病机制中的作用尚未阐明。因此，本研究的目的是确定肥大细胞在自身免疫性骨骼肌疾病的发展中的作用。对皮肌炎（DM）和多发性肌炎（PM）患者受累肌肉中肥大细胞的数量进行了检测。将肥大细胞缺陷型WBB 6 F1-KitW/KitWv小鼠（W/Wv小鼠）对多发性肌炎小鼠模型C蛋白诱导的肌炎（CIM）的易感性与野生型（WT）小鼠进行比较。用骨髓来源的肥大细胞（BMMCs）重建肥大细胞对W/Wv小鼠CIM易感性的影响也进行了评估。与DM患者相比，PM患者受累肌肉中肥大细胞的数量增加。与WT小鼠相比，W/Wv小鼠的CIM发病率和组织学评分显著降低。与WT小鼠相比，W/Wv小鼠CIM骨骼肌中的CD 8 + T细胞和巨噬细胞的数量减少。移植BMMCs可恢复W/Wv小鼠CIM的发生率和组织学评分。在CIM诱导后，WT小鼠骨骼肌中的血管通透性升高，但在W/Wv小鼠中未升高。肥大细胞参与炎性肌病的发病机制。
In addition to the pivotal roles of mast cells in allergic diseases, recent data suggest that mast cells play crucial roles in a variety of autoimmune responses. However, their roles in the pathogenesis of autoimmune skeletal muscle diseases have not been clarified despite their distribution in skeletal muscle. Therefore, the objective of this study is to determine the roles of mast cells in the development of autoimmune skeletal muscle diseases. The number of mast cells in the affected muscle was examined in patients with dermatomyositis (DM) or polymyositis (PM). The susceptibility of mast cell-deficient WBB6F1-KitW/KitWv mice (W/Wv mice) to a murine model of polymyositis, C protein-induced myositis (CIM), was compared with that of wild-type (WT) mice. The effect of mast cell reconstitution with bone marrow-derived mast cells (BMMCs) on the susceptibility of W/Wv mice to CIM was also evaluated. The number of mast cells in the affected muscle increased in patients with PM as compared with patients with DM. W/Wv mice exhibited significantly reduced disease incidence and histological scores of CIM as compared with WT mice. The number of CD8+ T cells and macrophages in the skeletal muscles of CIM decreased in W/Wv mice compared with WT mice. Engraftment of BMMCs restored the incidence and histological scores of CIM in W/Wv mice. Vascular permeability in the skeletal muscle was elevated in WT mice but not in W/Wv mice upon CIM induction. Mast cells are involved in the pathogenesis of inflammatory myopathy.
登录
查看更多内容
影响因子：
64.5
作者：
Suzuki K;Verma IM
通讯作者：
Verma IM
影响因子：
5.5
作者：
Studynkova, J. Tomasova;Charvat, F.;Vencovsky, J.
通讯作者：
Vencovsky, J.
影响因子：
--
作者：
Shrestha, Sheela;Wershil, Barry;Pachman, Lauren M.
通讯作者：
Pachman, Lauren M.
影响因子：
4.4
作者：
Geoffrey, Rhonda;Jia, Shuang;Hessner, Martin J.
通讯作者：
Hessner, Martin J.
在多发性硬化症的鼠模型中，肥大细胞对于早期发作和严重疾病至关重要。
影响因子：
15.3
作者：
Secor, V H;Secor, W E;Gutekunst, C A;Brown, M A
通讯作者：
Brown, M A