The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.
The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.
复制标题
抗真菌药物Isavuconazole抑制了人类巨细胞病毒（HCMV）的复制，并与抗HCMV药物协同作用。
DOI：
10.1016/j.antiviral.2021.105062
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发表时间：
2021-05
影响因子：
7.6
通讯作者：
Loregian A
中科院分区：
文献类型：
--
作者：
Mercorelli B;Celegato M;Luganini A;Gribaudo G;Lepesheva GI;Loregian A
We recently reported that some clinically approved antifungal drugs are potent inhibitors of human cytomegalovirus (HCMV). Here, we report the broad-spectrum activity against HCMV of isavuconazole (ICZ), a new extended spectrum triazolic antifungal drug. ICZ inhibited the replication of clinical isolates of HCMV as well as strains resistant to the currently available DNA polymerase inhibitors. The antiviral activity of ICZ against HCMV could be linked to the inhibition of human cytochrome P450 51 (hCYP51), an enzyme whose activity we previously demonstrated to be required for productive HCMV infection. Moreover, time-of-addition studies indicated that ICZ might have additional inhibitory effects during the first phase of HCMV replication. Importantly, ICZ showed synergistic antiviral activity in vitro when administered in combination with different approved anti-HCMV drugs at clinically relevant doses. Together, these results pave the way to possible future clinical studies aimed at evaluating the repurposing potential of ICZ in the treatment of HCMV-associated diseases.
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影响因子：
15.9
作者：
Mercorelli B;Palù G;Loregian A
通讯作者：
Loregian A
影响因子：
6.5
作者：
Hargrove, Tatiana Y.;Friggeri, Laura;Lepesheva, Galina I.
通讯作者：
Lepesheva, Galina I.
影响因子：
5.7
作者：
Chen B;Trang V;Lee A;Williams NS;Wilson AN;Epstein EH Jr;Tang JY;Kim J
通讯作者：
Kim J
影响因子：
4.9
作者：
Mercorelli, Beatrice;Muratore, Giulia;Loregian, Arianna
通讯作者：
Loregian, Arianna
影响因子：
7.6
作者：
Meutiawati, Febrina;Bezemer, Bodine;van Rij, Ronald P.
通讯作者：
van Rij, Ronald P.