Applications of Supercritical Anti-Solvent Process in Preparation of Solid Multicomponent Systems.
Applications of Supercritical Anti-Solvent Process in Preparation of Solid Multicomponent Systems.
复制标题
DOI：
10.3390/pharmaceutics13040475
复制
发表时间：
2021-04-01
期刊：
影响因子：
5.4
通讯作者：
Deng S
中科院分区：
文献类型：
--
作者：
Liu G;Li J;Deng S
固体多组分体系（SMS）在制药工业中发挥着越来越重要的作用，以改善活性药物成分（API）的理化性质。近年来，各种工艺已用于SMS制造。需要控制颗粒的固态性质，如尺寸、形态和晶型，以优化SMS配方。超临界抗溶剂（SAS）工艺利用超临界流体的独特和可调性质，为原料药固态性质的控制提供了巨大的希望。SAS技术已经从间歇模式发展到连续模式。本文综述了它们在SMS制备中的应用。许多药物共晶和固体分散体已通过SAS工艺成功生产，其中可以通过控制操作参数来很好地设计API的固态性质。的基本机制上的操纵固态性能进行了讨论，在线监测和计算技术的帮助下。随着研究的不断深入，在不久的将来，SAS工艺将为所需SMS的规模化和连续化生产做出巨大贡献。
Solid multicomponent systems (SMS) are gaining an increasingly important role in the pharmaceutical industry, to improve the physicochemical properties of active pharmaceutical ingredients (APIs). In recent years, various processes have been employed for SMS manufacturing. Control of the particle solid-state properties, such as size, morphology, and crystal form is required to optimize the SMS formulation. By utilizing the unique and tunable properties of supercritical fluids, supercritical anti-solvent (SAS) process holds great promise for the manipulation of the solid-state properties of APIs. The SAS techniques have been developed from batch to continuous mode. Their applications in SMS preparation are summarized in this review. Many pharmaceutical co-crystals and solid dispersions have been successfully produced via the SAS process, where the solid-state properties of APIs can be well designed by controlling the operating parameters. The underlying mechanisms on the manipulation of solid-state properties are discussed, with the help of on-line monitoring and computational techniques. With continuous researching, SAS process will give a large contribution to the scalable and continuous manufacturing of desired SMS in the near future.
登录
查看更多内容
影响因子：
3.9
作者：
Badens, Elisabeth;Masmoudi, Yasmine;Crampon, Christelle
通讯作者：
Crampon, Christelle
影响因子：
7.7
作者：
Cuadra, Isaac A.;Cabanas, Albertina;Pando, Concepcion
通讯作者：
Pando, Concepcion
影响因子：
5.8
作者：
BLEICH, J;MULLER, BW;WASSMUS, W
通讯作者：
WASSMUS, W
影响因子：
3.9
作者：
Cardoso, F. A. R.;Rezende, R. V. P.;Cardozo-Filho, L.
通讯作者：
Cardozo-Filho, L.
影响因子：
3.7
作者：
DIXON, DJ;JOHNSTON, KP;BODMEIER, RA
通讯作者：
BODMEIER, RA