Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines
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DOI：
10.1186/s13148-022-01296-6
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发表时间：
2022-06-22
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
不良出生结局，如早孕龄和低出生体重，可对发病率和死亡率产生持久影响，其影响会持续到成年。因此，确定导致下一代不良出生结果的产妇因素是一个优先事项。表观遗传时钟已经成为量化生物衰老和生理失调各种维度的有力工具，有望澄清母亲生物学和婴儿健康之间的关系，包括预测出生结果的母亲因素或状态。然而，探索母亲表观遗传年龄与出生结果之间关系的研究仍然很少。在这里，我们试图重复之前在美国样本中报道的一系列分析，使用一个更大的类似年龄的样本（n = 296），参与者在菲律宾进行了一项长期研究。前瞻性地确定新妊娠，在妊娠晚期收集干血斑样本，并获得分娩时胎龄和出生后后代体重的信息。使用Infinium EPIC阵列评估全基因组DNA甲基化。使用一套15个表观遗传时钟，我们只发现了一个显著的关系：在瘦素训练的表观遗传时钟上，年龄越大，分娩时的胎龄就越早（β = - 0.15, p = 0.009）。在其他29种预测胎龄和后代出生体重的关系中，没有一种具有统计学意义。在这个菲律宾妇女的样本中，捕获生物学和健康的多个维度的表观遗传时钟不能预测后代的出生结果。在线版本包含补充材料，可在10.1186/s13148-022-01296-6获得。
Adverse birth outcomes, such as early gestational age and low birth weight, can have lasting effects on morbidity and mortality, with impacts that persist into adulthood. Identifying the maternal factors that contribute to adverse birth outcomes in the next generation is thus a priority. Epigenetic clocks, which have emerged as powerful tools for quantifying biological aging and various dimensions of physiological dysregulation, hold promise for clarifying relationships between maternal biology and infant health, including the maternal factors or states that predict birth outcomes. Nevertheless, studies exploring the relationship between maternal epigenetic age and birth outcomes remain few. Here, we attempt to replicate a series of analyses previously reported in a US-based sample, using a larger similarly aged sample (n = 296) of participants of a long-running study in the Philippines. New pregnancies were identified prospectively, dried blood spot samples were collected during the third trimester, and information was obtained on gestational age at delivery and offspring weight after birth. Genome-wide DNA methylation was assessed with the Infinium EPIC array. Using a suite of 15 epigenetic clocks, we only found one significant relationship: advanced age on the epigenetic clock trained on leptin predicted a significantly earlier gestational age at delivery (β = − 0.15, p = 0.009). Of the other 29 relationships tested predicting gestational age and offspring birth weight, none were statistically significant. In this sample of Filipino women, epigenetic clocks capturing multiple dimensions of biology and health do not predict birth outcomes in offspring. The online version contains supplementary material available at 10.1186/s13148-022-01296-6.
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全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
3.4
作者：
Escobar, GJ;Clark, RH;Greene, JD
通讯作者：
Greene, JD
DOI：
10.1097/med.0b013e3283405921
发表时间：
2010-12
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Entringer S;Buss C;Wadhwa PD
通讯作者：
Wadhwa PD
DOI：
10.18632/aging.101414
发表时间：
2018-04-18
期刊：
Aging
影响因子：
--
作者：
Levine ME;Lu AT;Quach A;Chen BH;Assimes TL;Bandinelli S;Hou L;Baccarelli AA;Stewart JD;Li Y;Whitsel EA;Wilson JG;Reiner AP;Aviv A;Lohman K;Liu Y;Ferrucci L;Horvath S
通讯作者：
Horvath S
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S