Impact of life stage specific immune priming on invertebrate disease dynamics
Impact of life stage specific immune priming on invertebrate disease dynamics
复制标题
生命阶段特异性免疫启动对无脊椎动物疾病动态的影响
DOI：
10.1111/j.1600-0706.2011.19725.x
复制
发表时间：
2012
期刊：
影响因子：
3.4
通讯作者：
V. Rudolf
中科院分区：
文献类型：
--
作者：
A. Tate;V. Rudolf
宿主的免疫反应可以对宿主与病原体的相互作用产生重要影响，但在宿主的整个生活史中，对免疫的投资往往是动态变化的。一种形式的投资包括诱导针对以前遇到的病原体的启动免疫反应，以保护宿主免受再次感染。除了提供即时保护作用外，免疫启动还可提供两种针对病原体的“延迟”保护：跨生命阶段启动(个体启动)和跨世代启动(跨代启动)。因此，这两种类型的免疫启动都有可能在宿主-病原体相互作用中调节生活史的变异性，这可能对疾病流行和动态以及宿主种群的人口结构产生重要影响。在这里，我们建立了一个针对无脊椎动物宿主的阶段结构SIRS模型，以探索个体启动和跨代启动对感染流行率、宿主种群大小和种群年龄结构的相对和联合影响。我们的模型预测，这两种类型的免疫启动在平衡状态下都可以显著降低疾病患病率，但它们对种群规模和年龄结构的单独和联合影响取决于免疫保护和生殖之间的权衡程度以及生命阶段之间感染参数的对称性。该模型强调了基于生活史的免疫投资模式对疾病动态的潜在重要性，并强调了对代表昆虫免疫启动维持的参数进行广泛经验估计的必要性。
The immune response of a host can have important impacts on host-pathogen interactions, but investment in immunity often changes dynamically across the life history of a host. One form of investment involves the induction of a primed immune response against previously encountered pathogens that protects the host from re-infection. In addition to providing immediate protective effects, immune priming can also provide two types of ‘delayed’ protection against pathogens: priming across life stages (ontogenic priming) and priming across generations (trans-generational priming). Consequently both types of immune priming have the potential to mediate life history variability in host–pathogen interactions, which could have important consequences for disease prevalence and dynamics as well as for the demographic structure of the host population. Here we develop a stage-structured SIRS model for an invertebrate host to explore the relative and combined impact of ontogenic priming and trans-generational priming on infection prevalence, host population size, and population age structure. Our model predicts that both types of immune priming can dramatically reduce disease prevalence at equilibrium, but their individual and combined effects on population size and age structure depend on the magnitude of tradeoffs between immune protection and reproduction as well as on the symmetry of infection parameters between life stages. This model underscores the potential importance of life-history based immune investment patterns for disease dynamics and highlights the need for wide-spread empirical estimation of parameters that represent the maintenance of immune priming in insects.
DOI：
10.1093/imammb/dql021
发表时间：
2007-03
期刊：
Mathematical medicine and biology : a journal of the IMA
影响因子：
--
作者：
R. K. McCormack;L. Allen
通讯作者：
R. K. McCormack;L. Allen