Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas.
Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas.
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层粘连蛋白在头颈部鳞癌中的潜在治疗意义
DOI：
10.3390/cancers13081890
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发表时间：
2021-04-15
期刊：
影响因子：
5.2
通讯作者：
Palumbo Júnior A
中科院分区：
文献类型：
--
作者：
Meireles Da Costa N;Mendes FA;Pontes B;Nasciutti LE;Ribeiro Pinto LF;Palumbo Júnior A
头颈癌 (HNC) 每年导致全球约 500,000 例新发肿瘤病例，以上呼吸消化道恶性肿瘤为代表，特别是出现在口腔、喉和咽组织中。因此，由于上呼吸消化器官之间的生物多样性，以及与其恶性转化相关的危险因素的异质性，HNC 行为和预后似乎根据肿瘤部位的不同而有很大差异。然而，尽管头颈部肿瘤具有异质性，但鳞状细胞癌 (SCC) 代表了主要的组织病理学 HNC 亚型。从这个意义上说，据报道，鳞状细胞癌肿瘤生物学与细胞外基质隔室内的失调密切相关。因此，已经表明，层粘连蛋白在调节与头颈鳞状细胞癌（HNSCC）进展相关的关键事件中发挥着显着作用，这开启了层粘连蛋白可能代表 HNSCC 自然史的汇合点的可能性。头颈鳞状细胞癌（HNSCC）是世界上最常见和致命的肿瘤之一，主要发生在口腔、咽和喉组织中。鳞状上皮稳态由细胞外基质 (ECM) 支持，该区室的改变对于癌症的发生和进展至关重要。层粘连蛋白是 ECM 的基本成分，代表基底膜 (BM) 的主要成分之一，支持其对 HNSCC 发生和进展的贡献的数据已在口腔鳞状细胞癌中得到广泛探索。层粘连蛋白亚型 111 (LN-111) 和 332 (LN-332) 是与恶性转化相关的主要亚型，由于其参与调节与 HNSCC 癌变相关的多个途径，包括 EGFR/MAPK 信号途径的激活，因此有助于增殖、粘附、迁移、侵袭和转移。因此，它提请人们注意层粘连蛋白可能代表 HNSCC 自然史的汇聚点，以及这些肿瘤的有吸引力的潜在治疗靶点的可能性。
Head and neck cancers (HNC) account for approximately 500,000 new cases of tumors annually worldwide and are represented by upper aerodigestive tract malignant neoplasms, which particularly arise in oral cavity, larynx, and pharynx tissues. Thus, due to the biological diversity between the upper aerodigestive organs, and to the heterogeneity of risk factors associated with their malignant transformation, HNC behavior, and prognosis seem to strongly vary according to the tumor site. However, despite to the heterogeneity which characterizes head and neck tumors, squamous cell carcinomas (SCC) represent the predominant histopathologic HNC subtype. In this sense, it has been reported that SCC tumor biology is strongly associated with deregulations within the extracellular matrix compartment. Accordingly, it has been shown that laminin plays a remarkable role in the regulation of crucial events associated with head and neck squamous cell carcinomas (HNSCC) progression, which opens the possibility that laminin may represent a convergence point in HNSCC natural history. Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Laminin subtypes 111 (LN-111) and 332 (LN-332) are the main isoforms associated with malignant transformation, contributing to proliferation, adhesion, migration, invasion, and metastasis, due to its involvement in the regulation of several pathways associated with HNSCC carcinogenesis, including the activation of the EGFR/MAPK signaling pathway. Therefore, it draws attention to the possibility that laminin may represent a convergence point in HNSCC natural history, and an attractive potential therapeutic target for these tumors.
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