Early postoperative epidermal growth factor receptor inhibition: safety and effectiveness in inhibiting microscopic residual of oral squamous cell carcinoma in vivo.
Early postoperative epidermal growth factor receptor inhibition: safety and effectiveness in inhibiting microscopic residual of oral squamous cell carcinoma in vivo.
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DOI：
10.1002/hed.22961
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发表时间：
2013-03
影响因子：
2.9
通讯作者：
Myers, Jeffrey N.
中科院分区：
文献类型：
--
作者：
Sano, Daisuke;Gule, Maria K.;Rosenthal, David I.;Bell, Diana;Yates, Jeremy;El-Naggar, Adel K.;Myers, Jeffrey N.
关键词：
晚期口腔鳞状细胞癌(OSCC)术后局部失败的原因是创面愈合过程中残留的肿瘤细胞可能受到表皮生长因子受体(EGFR)配体的刺激而重新生长。测定口腔鳞癌切除后和远端皮瓣供区引流液中EGFR配体的水平。建立了微小残留口腔鳞癌的小鼠模型，并用西妥昔单抗治疗，以测量肿瘤的生长、存活率和颈淋巴转移。还建立了小鼠伤口愈合模型，以评估EGFR抗体对伤口愈合过程的影响。EGFR配体存在于口腔鳞状细胞癌切除部位。EGFR靶向治疗可以延缓口腔鳞癌微小残留病模型中肿瘤的再生长，而不会对局部伤口愈合产生明显影响。这些结果为临床评价这种治疗局部晚期口腔鳞癌的方法提供了强有力的理论基础。
The local-regional failure of advanced oral squamous cell carcinoma (OSCC) after surgery results from the re-growth of residual tumor cells that may be stimulated by epidermal growth factor receptor (EGFR) ligands during the wound-healing process. The level of EGFR ligands in human drain fluids from OSCC resection and remote flap donor site were determined. A mouse model of microscopic residual OSCC was established and treated with cetuximab to measure tumor growth, survival, and cervical lymph node metastases. A mouse model of wound-healing was also established to assess the effect of an EGFR antibody on the wound-healing process. EGFR ligands are found in sites from OSCC resection. EGFR targeted therapy can delay tumor re-growth in a microscopic residual disease model of OSCC without significant effects on local wound-healing. These results provide a strong rationale for clinical evaluation of this approach to treat patients with local-regionally advanced OSCC.
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影响因子：
45.3
作者：
Rosenthal, David I.;Harris, Jonathan;Ang, K. Kian
通讯作者：
Ang, K. Kian
影响因子：
158.5
作者：
Bernier, J;Domenge, C;van Glabbeke, M
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van Glabbeke, M
影响因子：
158.5
作者：
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通讯作者：
Ang, KK
DOI：
10.1016/s0360-3016(97)00152-1
发表时间：
1997-08-01
影响因子：
7
作者：
Parsons, JT;Mendenhall, WM;Million, RR
通讯作者：
Million, RR
影响因子：
158.5
作者：
BROWN, GL;NANNEY, LB;LYNCH, JB
通讯作者：
LYNCH, JB