Lab-on-a-chip sensor for detection of highly electronegative heavy metals by anodic stripping voltammetry.
Lab-on-a-chip sensor for detection of highly electronegative heavy metals by anodic stripping voltammetry.
复制标题
DOI：
10.1007/s10544-011-9539-1
复制
发表时间：
2011-08
影响因子：
2.8
通讯作者：
Papautsky, Ian
中科院分区：
文献类型：
--
作者：
Jothimuthu, Preetha;Wilson, Robert A.;Herren, Josi;Haynes, Erin N.;Heineman, William R.;Papautsky, Ian
关键词：
本工作描述了一个芯片上的实验室传感器的电化学检测的高度电负性的重金属，如锰和锌的阳极溶出伏安法的发展。该传感器由一个三电极系统组成，具有铋工作电极、Ag/AgCl参比电极和Au辅助电极。在辅助电极处的水解是此类电化学传感器中的关键挑战，因为其发生严重限制了检测负电性金属的能力。使用铋工作电极是因为其相对于常规汞电极具有相当的负检测窗口和降低的毒性。通过优化传感器布局和工作电极表面，水解的影响大大降低，电位窗口扩展到−0.3至−1.9 V范围（相对于Ag/AgCl参比电极），这比传统的Au、Pt或碳电极的可能性要负得多。所描述的芯片实验室传感器首次允许可靠和灵敏地检测高电负性锰。铋电极的有利性能与其环境友好性质相结合，使得所述传感器对于需要一次性芯片的应用具有吸引力。随着进一步的开发和集成的样品制备，芯片实验室可以转换成用于监测血液中重金属的即时平台（例如，锰暴露评估）。
This work describes development of a lab-on-a-chip sensor for electrochemical detection of highly electro-negative heavy metals such as manganese and zinc by anodic stripping voltammetry. The sensor consists of a three-electrode system, with a bismuth working electrode, a Ag/AgCl reference electrode, and a Au auxiliary electrode. Hydrolysis at the auxiliary electrode is a critical challenge in such electrochemical sensors as its onset severely limits the ability to detect electronegative metals. The bismuth working electrode is used due to its comparable negative detection window and reduced toxicity with respect to a conventional mercury electrode. Through optimization of the sensor layout and the working electrode surface, effects of hydrolysis were substantially reduced and the potential window was extended to the −0.3 to −1.9 V range (vs. Ag/AgCl reference electrode), which is far more negative than what is possible with conventional Au, Pt, or carbon electrodes. The described lab-on-a-chip sensor for the first time permits reliable and sensitive detection of the highly electronegative manganese. The favorable performance of the bismuth electrode coupled with its environmentally-friendly nature make the described sensor attractive for applications where disposable chips are desirable. With further development and integrated sample preparation, the lab-on-a-chip may be converted into a point-of-care platform for monitoring heavy metals in blood (e.g., assessment of manganese exposure).
登录
查看更多内容
影响因子：
3.4
作者：
Cowan DM;Zheng W;Zou Y;Shi X;Chen J;Rosenthal FS;Fan Q
通讯作者：
Fan Q
影响因子：
6.2
作者：
Hutton, Emily A.;Hocevar, Sarno B.;Ogorevc, Bozidar
通讯作者：
Ogorevc, Bozidar
影响因子：
3
作者：
Skogvold, SM;Mikkelsen, O;Schroder, KH
通讯作者：
Schroder, KH
影响因子：
4.8
作者：
Sun, HZ;Li, HY;Sadler, PJ
通讯作者：
Sadler, PJ
影响因子：
1.1
作者：
Tarasova, V. A.
通讯作者：
Tarasova, V. A.