Manganese exposure among smelting workers: relationship between blood manganese-iron ratio and early onset neurobehavioral alterations.
Manganese exposure among smelting workers: relationship between blood manganese-iron ratio and early onset neurobehavioral alterations.
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DOI：
10.1016/j.neuro.2009.02.005
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发表时间：
2009-11
期刊：
影响因子：
3.4
通讯作者：
Fan Q
中科院分区：
文献类型：
--
作者：
Cowan DM;Zheng W;Zou Y;Shi X;Chen J;Rosenthal FS;Fan Q
检测锰中毒早期神经行为改变的生物标志物仍然未知。本研究的目的是使用神经行为测试电池，以确定锰引起的运动和记忆功能障碍的微妙变化，并与可量化的神经功能障碍，以建立锰暴露指数，如血锰-铁比（MIR）。共招募了323名受试者，分为对照组（n = 106）、低暴露组（122）和高暴露组（95）。测试组由标准测试程序组成，包括九孔和槽型稳定性测试仪、本顿视觉保持测试和普渡钉板协调测试。未观察到显著的健康问题或临床诊断的神经功能障碍。本顿测验未发现锰作业工人记忆力异常，槽测验和九孔测验也未发现受试者动、静态稳定性异常。普渡钉板试验显示，无论锰暴露条件如何，所有研究参与者的精细运动协调性均出现显著的年龄相关性下降。锰暴露显著加剧了这种与年龄相关的恶化。统计建模显示，血浆和红细胞MIR（即，pMIR和eMIR）与Purdue pegboard评分相关。在MIR高于临界值（COV）的所有受试者中，pMIR与钉板评分显著相关（r =-0.261，p = 0.002），而对于40岁以上的受试者，eMIR而不是pMIR与钉板表现下降相关（r =-0.219，p = 0.069）。当考虑到这两个因素时（即，年龄> 40岁和MIR > COV），只有pMIR与钉板评分呈负相关。结合它们在锰暴露评估中的有用性，我们建议血液Mn-Fe比值不仅可以作为锰暴露评估的合理生物标志物，而且可以作为健康风险评估的生物标志物。
A biomarker for detection of early onset neurobehavioral alterations in manganism remains unknown. The purpose of this study was to use a neurobehavioral test battery to identify subtle changes in Mn-induced motor and memory dysfunction and to relate the quantifiable neurological dysfunction to an established Mn-exposure index such as blood manganese–iron ratio (MIR). A total of 323 subjects were recruited to control (n = 106), low-exposure (122), and high-exposure (95) groups. The test battery consisted of standard testing procedures including the nine-hole and groove-type steadiness tester, Benton visual retention test, and Purdue pegboard coordination test. No significant health problems or clinically diagnosed neurological dysfunctions were observed. Benton test did not reveal any abnormal memory deficits among Mn-exposed smelters, nor did the groove and nine-hole tests detect any abnormality in dynamic and static steadiness in tested subjects. Purdue pegboard test showed a remarkable age-related decline in fine movement coordination among all study participants regardless of the Mn-exposure condition. Mn exposure significantly exacerbated this age-related deterioration. Statistical modeling revealed that the plasma and erythrocyte MIR (i.e., pMIR and eMIR, respectively) were associated with Purdue pegboard scores. Among all subjects whose MIR were above the cut-off value (COV), pMIR was significantly correlated with pegboard scores (r = −0.261, p = 0.002), whereas for those subjects over the age of 40, the eMIR, but not pMIR, was associated with declined pegboard performance (r = −0.219, p = 0.069). When both factors were taken into account (i.e., age > 40 and MIR > the COV), only pMIR was inversely associated with pegboard scores. Combining their usefulness in Mn-exposure assessment, we recommend that the blood Mn–Fe ratio may serve as a reasonable biomarker not only for assessment of Mn exposure but also for health risk assessment.
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影响因子：
3.9
作者：
Ferman, Tanis J.;Smith, Glenn E.;Dickson, Dennis W.
通讯作者：
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DOI：
10.1007/s00420-003-0491-0
发表时间：
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